Protection by tetramethylpyrazine in acute absolute ethanol-induced gastric lesions.

Chi Feng Liu, Chun Ching Lin, Lean Teik Ng, Song Chow Lin

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)


Acute oral administration of absolute ethanol (1.0 ml/kg) to fasting rats produced extensive necrosis of the gastric mucosa within 1 h. Pretreatment 30 min before administration of ethanol with oral tetramethylpyrazine (TMP) prevented this necrosis. Gross examination of the gastric mucosa of rats that received TMP showed fewer gastric lesions than that of rats who did not receive TMP. TMP pretreatment in rats exhibited superoxide scavenging activity in absolute ethanol-induced lipid peroxidation in gastric mucosal homogenates. TMP added in vitro to gastric homogenates made from control rats also showed scavenging activity. We conclude that the gastric protective mechanism of TMP could be attributed, at least in part, to its ability to inhibit lipid peroxidation and hence indirectly protect the gastric mucosa from oxidative stress.
頁(從 - 到)395-400
期刊Journal of Biomedical Science
出版狀態已發佈 - 9月 2002

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)


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