Prospective Therapeutic Applications of Platelet Extracellular Vesicles

Jancy Johnson, Yu Wen Wu, Chantelle Blyth, Gregor Lichtfuss, Hadi Goubran, Thierry Burnouf

研究成果: 雜誌貢獻回顧型文獻同行評審

1 引文 斯高帕斯(Scopus)

摘要

There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for regenerative medicine and drug delivery. Blood-borne platelets represent a source of therapeutic EVs that is so far largely unexplored. Advantages of platelets as a cellular source of EVs include their established clinical value, regulated collection procedures, availability in a concentrated form, propensity to generate EVs, and unique composition and tissue-targeting capacity. This review analyzes the unique potential of platelet-derived (p-) EVs as therapeutic modalities and presents their inherent translational advantages for hemostasis, for regenerative medicine, and as drug-delivery vehicles.

原文英語
期刊Trends in Biotechnology
DOIs
出版狀態接受/付印 - 2020

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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