Propofol reduces nitric oxide biosynthesis in lipopolysaccharide-activated macrophages by downregulating the expression of inducible nitric oxide synthase

Ruei-Ming Chen, Gong-Jhe Wu, Yu-Ting Tai, Wei Zen Sun, Yi Ling Lin, Wen Chi Jean, Ta-Liang Chen

研究成果: 雜誌貢獻文章同行評審

45 引文 斯高帕斯(Scopus)

摘要

Nitric oxide is an active oxidant that contributes to the physiology and pathophysiology of macrophages. Propofol has been widely used in intravenous anesthesia. It possess antioxidant and immunomodulating effects. This study aimed to evaluate the effects of propofol on nitric oxide production in lipopolysaccharide-activated macrophages. Exposure of macrophages to propofol (25, 50 and 75 μM), to lipopolysaccharide (0.5, 1, 1.5 and 2 ng/ml) or to a combination ofpropofol and lipopolysaccharide did not affect cell viability. However, propofol at 100 μM led to significant cell death (P3 versus 92±6×103 arbitrary units, P2 versus 30±4×102 arbitrary units, P
原文英語
頁(從 - 到)418-423
頁數6
期刊Archives of Toxicology
77
發行號7
DOIs
出版狀態已發佈 - 7月 1 2003

ASJC Scopus subject areas

  • 毒理學
  • 健康、毒理學和誘變

指紋

深入研究「Propofol reduces nitric oxide biosynthesis in lipopolysaccharide-activated macrophages by downregulating the expression of inducible nitric oxide synthase」主題。共同形成了獨特的指紋。

引用此