Prophylactic and therapeutic effects of honey on radiochemotherapy-induced mucositis: a meta-analysis of randomized controlled trials

Tzu Ming Liu, Yu Wei Luo, Ka Wai Tam, Chia Chin Lin, Tsai Wei Huang

研究成果: 雜誌貢獻回顧型文獻

2 引文 (Scopus)

摘要

© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Oral mucositis is a common side effect of radiochemotherapy and may adversely affect the patients’ quality of life (QoL). Honey application may reduce the mucositis grade in patients. Here, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the prophylactic and therapeutic effects of honey on radiochemotherapy-induced oral mucositis. Methods: Publications on RCTs were extracted from the PubMed, Embase, CINAHL, and Cochrane Library databases. The primary outcomes were mucositis grades and pain scores. Secondary outcomes were the recovery time and QoL. The study was registered with PROSPERO (number CRD42018108486). Results: Nineteen RCTs, involving 1276 patients, were reviewed. Honey considerably mitigated oral mucositis in both prophylactic and therapeutic phases. In the prophylactic phase, intolerable mucositis development was significantly prevented in the honey-treated group (RR = 0.18, 95% confidence interval [CI] = 0.09 to 0.41). Patients treated with honey showed significant decrease in pain scores in the first month of treatment (weighted mean difference [WMD] = − 3.25, 95% CI = − 4.41 to − 2.09) and at the end of the treatment (WMD = − 2.32, 95% CI = − 4.47 to − 0.18). Conclusion: Honey, which is relatively cheap and easily available, prevented mucositis and effectively mitigate mucositis in patients after radiochemotherapy. Moreover, it significantly reduced the mucositis grade and engendered a fast and painless healing process. Therefore, honey use during and after radiochemotherapy is recommended for mucositis prevention and treatment.
原文英語
頁(從 - 到)2361-2370
頁數10
期刊Supportive Care in Cancer
27
發行號7
早期上線日期三月 2019
DOIs
出版狀態已發佈 - 七月 2019

指紋

Mucositis
Honey
Chemoradiotherapy
Therapeutic Uses
Meta-Analysis
Randomized Controlled Trials
Stomatitis
Confidence Intervals
Quality of Life
Pain
Therapeutics
PubMed
Libraries
Germany
Publications
Databases

ASJC Scopus subject areas

  • Oncology

引用此文

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title = "Prophylactic and therapeutic effects of honey on radiochemotherapy-induced mucositis: a meta-analysis of randomized controlled trials",
abstract = "{\circledC} 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Oral mucositis is a common side effect of radiochemotherapy and may adversely affect the patients’ quality of life (QoL). Honey application may reduce the mucositis grade in patients. Here, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the prophylactic and therapeutic effects of honey on radiochemotherapy-induced oral mucositis. Methods: Publications on RCTs were extracted from the PubMed, Embase, CINAHL, and Cochrane Library databases. The primary outcomes were mucositis grades and pain scores. Secondary outcomes were the recovery time and QoL. The study was registered with PROSPERO (number CRD42018108486). Results: Nineteen RCTs, involving 1276 patients, were reviewed. Honey considerably mitigated oral mucositis in both prophylactic and therapeutic phases. In the prophylactic phase, intolerable mucositis development was significantly prevented in the honey-treated group (RR = 0.18, 95{\%} confidence interval [CI] = 0.09 to 0.41). Patients treated with honey showed significant decrease in pain scores in the first month of treatment (weighted mean difference [WMD] = − 3.25, 95{\%} CI = − 4.41 to − 2.09) and at the end of the treatment (WMD = − 2.32, 95{\%} CI = − 4.47 to − 0.18). Conclusion: Honey, which is relatively cheap and easily available, prevented mucositis and effectively mitigate mucositis in patients after radiochemotherapy. Moreover, it significantly reduced the mucositis grade and engendered a fast and painless healing process. Therefore, honey use during and after radiochemotherapy is recommended for mucositis prevention and treatment.",
keywords = "Chemotherapy, Honey, Meta-analysis, Mucositis, Radiotherapy",
author = "Liu, {Tzu Ming} and Luo, {Yu Wei} and Tam, {Ka Wai} and Lin, {Chia Chin} and Huang, {Tsai Wei}",
year = "2019",
month = "7",
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pages = "2361--2370",
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TY - JOUR

T1 - Prophylactic and therapeutic effects of honey on radiochemotherapy-induced mucositis

T2 - a meta-analysis of randomized controlled trials

AU - Liu, Tzu Ming

AU - Luo, Yu Wei

AU - Tam, Ka Wai

AU - Lin, Chia Chin

AU - Huang, Tsai Wei

PY - 2019/7

Y1 - 2019/7

N2 - © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Oral mucositis is a common side effect of radiochemotherapy and may adversely affect the patients’ quality of life (QoL). Honey application may reduce the mucositis grade in patients. Here, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the prophylactic and therapeutic effects of honey on radiochemotherapy-induced oral mucositis. Methods: Publications on RCTs were extracted from the PubMed, Embase, CINAHL, and Cochrane Library databases. The primary outcomes were mucositis grades and pain scores. Secondary outcomes were the recovery time and QoL. The study was registered with PROSPERO (number CRD42018108486). Results: Nineteen RCTs, involving 1276 patients, were reviewed. Honey considerably mitigated oral mucositis in both prophylactic and therapeutic phases. In the prophylactic phase, intolerable mucositis development was significantly prevented in the honey-treated group (RR = 0.18, 95% confidence interval [CI] = 0.09 to 0.41). Patients treated with honey showed significant decrease in pain scores in the first month of treatment (weighted mean difference [WMD] = − 3.25, 95% CI = − 4.41 to − 2.09) and at the end of the treatment (WMD = − 2.32, 95% CI = − 4.47 to − 0.18). Conclusion: Honey, which is relatively cheap and easily available, prevented mucositis and effectively mitigate mucositis in patients after radiochemotherapy. Moreover, it significantly reduced the mucositis grade and engendered a fast and painless healing process. Therefore, honey use during and after radiochemotherapy is recommended for mucositis prevention and treatment.

AB - © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Oral mucositis is a common side effect of radiochemotherapy and may adversely affect the patients’ quality of life (QoL). Honey application may reduce the mucositis grade in patients. Here, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the prophylactic and therapeutic effects of honey on radiochemotherapy-induced oral mucositis. Methods: Publications on RCTs were extracted from the PubMed, Embase, CINAHL, and Cochrane Library databases. The primary outcomes were mucositis grades and pain scores. Secondary outcomes were the recovery time and QoL. The study was registered with PROSPERO (number CRD42018108486). Results: Nineteen RCTs, involving 1276 patients, were reviewed. Honey considerably mitigated oral mucositis in both prophylactic and therapeutic phases. In the prophylactic phase, intolerable mucositis development was significantly prevented in the honey-treated group (RR = 0.18, 95% confidence interval [CI] = 0.09 to 0.41). Patients treated with honey showed significant decrease in pain scores in the first month of treatment (weighted mean difference [WMD] = − 3.25, 95% CI = − 4.41 to − 2.09) and at the end of the treatment (WMD = − 2.32, 95% CI = − 4.47 to − 0.18). Conclusion: Honey, which is relatively cheap and easily available, prevented mucositis and effectively mitigate mucositis in patients after radiochemotherapy. Moreover, it significantly reduced the mucositis grade and engendered a fast and painless healing process. Therefore, honey use during and after radiochemotherapy is recommended for mucositis prevention and treatment.

KW - Chemotherapy

KW - Honey

KW - Meta-analysis

KW - Mucositis

KW - Radiotherapy

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U2 - 10.1007/s00520-019-04722-3

DO - 10.1007/s00520-019-04722-3

M3 - Review article

C2 - 30919153

AN - SCOPUS:85064215228

VL - 27

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EP - 2370

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

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