Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features

Shyr Yi Lin, Kun Tu Yeh, Willian Tzu Liang Chen, Hung Chang Chen, Shou Tung Chen, Hung Yi Chiou, Jan Gowth Chang

研究成果: 雜誌貢獻文章

39 引文 (Scopus)

摘要

Aberrant promoter methylation of CpG islands of tumor suppressor genes inhibits expression of the genes and may lead to tumorigenesis. We investigated the aberrant methylation profile of potential tumor suppressor genes of p15, p16, SOCS-1, and Wnt signaling pathway in colorectal cancers and correlated the data with clinical findings. Cancerous and nearby non-cancerous tissues of 185 sporadic colorectal cancer samples were studied. Methylation specific PCR was performed to explore the mechanism of inactivation in p15, p16, SOCS-1, E-cadherin, APC, GSK-3β, and Axin1 genes. Aberrant promoter methylation in p15, p16, SOCS-1, E-cadherin, APC, GSK-3β, and Axin1 genes were 5.9, 7.0, 3.8, 5.9, 12.4, 2.2, and 0% for cancerous tissues, respectively, whereas the frequencies were 3.8, 0, 0, 7.0, 2.7, 0.5, and 0% for nearby non-cancerous tissues, respectively. The frequency of aberrant promoter methylation of cancerous tissues was significant higher than non-cancerous tissues in p16, SOCS-1, and APC genes (p

原文英語
頁(從 - 到)341-348
頁數8
期刊Oncology Reports
11
發行號2
出版狀態已發佈 - 二月 2004

指紋

Tumor Suppressor Genes
Methylation
Colorectal Neoplasms
Glycogen Synthase Kinase 3
Cadherins
APC Genes
Genes
CpG Islands
Wnt Signaling Pathway
Carcinogenesis
Gene Expression
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

引用此文

Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features. / Lin, Shyr Yi; Yeh, Kun Tu; Chen, Willian Tzu Liang; Chen, Hung Chang; Chen, Shou Tung; Chiou, Hung Yi; Chang, Jan Gowth.

於: Oncology Reports, 卷 11, 編號 2, 02.2004, p. 341-348.

研究成果: 雜誌貢獻文章

Lin, Shyr Yi ; Yeh, Kun Tu ; Chen, Willian Tzu Liang ; Chen, Hung Chang ; Chen, Shou Tung ; Chiou, Hung Yi ; Chang, Jan Gowth. / Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features. 於: Oncology Reports. 2004 ; 卷 11, 編號 2. 頁 341-348.
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