Prolonged cytogenetic and hematologic remission of blastic transformation in chronic granulogytic leukemia

George P. Canellos, Jacqueline Whang‐Peng, Lowell Schnipper, Clarence H. Brown

研究成果: 雜誌貢獻文章

19 引文 (Scopus)

摘要

A patient with blastic transformation of Ph′ positive chronic granulocytic leukemia is presented in whom a long drug‐induced remission was achieved. Serial cytogenetic studies were performed through the course of the illness which demonstrated a major hypodiploid cell line associated with the blastic leukemia. Remission was accompanied by a return to the diploid chromosomal constitution which characterized the chronic phase of the disease. An unusual responsiveness to the effects of vincristine and prednisone was demonstrated by the case, which resulted in a survival of 28 months following the onset of blastic transformation. Eventual refractoriness to therapy was associated with a new cell line suggesting a pattern of clonal evolution. The Ph′ chromosome was present throughout the course of the disease.
原文英語
頁(從 - 到)288-293
頁數6
期刊Cancer
30
發行號1
DOIs
出版狀態已發佈 - 一月 1 1972
對外發佈Yes

指紋

Cytogenetics
Leukemia
Clonal Evolution
Cell Line
Constitution and Bylaws
Vincristine
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Prednisone
Diploidy
Chronic Disease
Chromosomes
Survival
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

引用此文

Prolonged cytogenetic and hematologic remission of blastic transformation in chronic granulogytic leukemia. / Canellos, George P.; Whang‐Peng, Jacqueline; Schnipper, Lowell; Brown, Clarence H.

於: Cancer, 卷 30, 編號 1, 01.01.1972, p. 288-293.

研究成果: 雜誌貢獻文章

Canellos, George P. ; Whang‐Peng, Jacqueline ; Schnipper, Lowell ; Brown, Clarence H. / Prolonged cytogenetic and hematologic remission of blastic transformation in chronic granulogytic leukemia. 於: Cancer. 1972 ; 卷 30, 編號 1. 頁 288-293.
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