摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 1641-1645 |
| 頁數 | 5 |
| 期刊 | International Journal of Ophthalmology |
| 卷 | 9 |
| 發行號 | 9 |
| DOIs | |
| 出版狀態 | 已發佈 - 十月 22 2009 |
| 對外發佈 | Yes |
指紋
Keywords
- (R, R)-XY-10
- (S, S)-XY-10
- Age-related macular degeneration
- ARPE-19 cells
- Human umbilical vein endothelial cells
- Proliferation
ASJC Scopus subject areas
- Ophthalmology
引用此文
Proliferation of retinal pigment epithelial cells induced by (R, R)-XY-10 and (S, S)-XY-10 and their action mechanisms. / Cheng, Yu Wen; Wang, Yu Liang; Zhang, Yi Hua; Peng, Si Xun; Chiou, George C.Y.
於: International Journal of Ophthalmology, 卷 9, 編號 9, 22.10.2009, p. 1641-1645.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Proliferation of retinal pigment epithelial cells induced by (R, R)-XY-10 and (S, S)-XY-10 and their action mechanisms
AU - Cheng, Yu Wen
AU - Wang, Yu Liang
AU - Zhang, Yi Hua
AU - Peng, Si Xun
AU - Chiou, George C.Y.
PY - 2009/10/22
Y1 - 2009/10/22
N2 - • AIM: To investigate the mechanism of proliferation effect induced by (R, R)-XY-10 and (S, S)-XY-10 on retinal pigmented epithelial cells (ARPE-19). • METHODS: Human retinal pigmented epithelial cells (ARPE-19) and human umbilical vein endothelial cells (HUVECs) were used to investigate the effect of (R, R)-XY-10 and (S, S)-XY-10 on cell growth, and their mechanisms of proliferative action by using ERKinverted commas AKTinverted commas PI3Kinverted commas Protein kinase C (PKC)and Nitric oxide synthase (NOS) inhibitors. RESULTS: (R, R)-XY-10 and (S, S)-XY-10 dose-dependently increased ARPE-19 cell proliferation, but not on HUVECs. When treated with proliferative inhibitors, H7 (5μ mol/L)inverted commas hypericin (20μ mol/L)inverted commas PD98059 (2μ mol/L)inverted commas LY294002 (50μ mol/L)inverted commas SH-5 (10μ mol/L) and L-NAME (100μ mol/L), the proliferative effect was reduced by H7inverted commas hypericininverted commas PD98059 and LY294002, but not by SH-5 and L-NAME. • CONCLUSION: (R, R)-XY-10 and (S, S)-XY-10 can induce cell proliferation through MAPK and PI3K dependent pathway.
AB - • AIM: To investigate the mechanism of proliferation effect induced by (R, R)-XY-10 and (S, S)-XY-10 on retinal pigmented epithelial cells (ARPE-19). • METHODS: Human retinal pigmented epithelial cells (ARPE-19) and human umbilical vein endothelial cells (HUVECs) were used to investigate the effect of (R, R)-XY-10 and (S, S)-XY-10 on cell growth, and their mechanisms of proliferative action by using ERKinverted commas AKTinverted commas PI3Kinverted commas Protein kinase C (PKC)and Nitric oxide synthase (NOS) inhibitors. RESULTS: (R, R)-XY-10 and (S, S)-XY-10 dose-dependently increased ARPE-19 cell proliferation, but not on HUVECs. When treated with proliferative inhibitors, H7 (5μ mol/L)inverted commas hypericin (20μ mol/L)inverted commas PD98059 (2μ mol/L)inverted commas LY294002 (50μ mol/L)inverted commas SH-5 (10μ mol/L) and L-NAME (100μ mol/L), the proliferative effect was reduced by H7inverted commas hypericininverted commas PD98059 and LY294002, but not by SH-5 and L-NAME. • CONCLUSION: (R, R)-XY-10 and (S, S)-XY-10 can induce cell proliferation through MAPK and PI3K dependent pathway.
KW - (R, R)-XY-10
KW - (S, S)-XY-10
KW - Age-related macular degeneration
KW - ARPE-19 cells
KW - Human umbilical vein endothelial cells
KW - Proliferation
KW - (R, R)-XY-10
KW - (S, S)-XY-10
KW - Age-related macular degeneration
KW - ARPE-19 cells
KW - Human umbilical vein endothelial cells
KW - Proliferation
UR - http://www.scopus.com/inward/record.url?scp=70350069740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350069740&partnerID=8YFLogxK
U2 - 10.3969/j.issn.1672-5123.2009.09.001
DO - 10.3969/j.issn.1672-5123.2009.09.001
M3 - Article
AN - SCOPUS:70350069740
VL - 9
SP - 1641
EP - 1645
JO - International Eye Science
JF - International Eye Science
SN - 2222-3959
IS - 9
ER -