Progressive remodeling of the atrial substrate - A novel finding from consecutive voltage mapping in patients with recurrence of atrial fibrillation after catheter ablation

Li Wei Lo, Ching Tai Tai, Yenn Jiang Lin, Shih Lin Chang, Wanwarang Wongcharoen, Sheng Hsiung Chang, Ming Hsiung Hsieh, Ta Chuan Tuan, Ameya R. Udyavar, Yi Jen Chen, Hsuan Ming Tsao, Shih Ann Chen

研究成果: 雜誌貢獻文章

71 引文 斯高帕斯(Scopus)


Atrial Substrate in Recurrent Atrial Fibrillation. Background: Atrial substrate properties have been demonstrated to be related to atrial arrhythmias. This study investigated whether the atrial substrate exhibits progressive remodeling in patients with recurrence of atrial fibrillation (AF) after catheter ablation. Methods and Results: Fifteen consecutive AF patients (52 ± 12 years old, 12 males) underwent the same mapping technique (NavX, St. Jude Medical, Minnetonka, MN, USA) and same ablation technique for primary AF and recurrence of AF (170 ± 66 days after the first procedure). The bipolar mean peak-to-peak voltage (PPV) of the global left atrium during sinus rhythm significantly decreased in the second procedure (2.25 ± 0.62 vs. 1.79 ± 0.60 mV, P = 0.008). Also, the percentage of the surface area of the low voltage zone (LVZ; less than 0.5 mV) in the left atrium increased from 6 ± 4% to 13 ± 6% (P = 0.001) in the second procedure. There was no significant change in the right atrial bipolar mean PPV or surface area of the LVZ in the second procedure. Conclusion: Atrial substrate remodeling with a progressive decrease in the left atrial voltage was demonstrated in patients with recurrent AF.
頁(從 - 到)258-265
期刊Journal of Cardiovascular Electrophysiology
出版狀態已發佈 - 三月 2007


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology