Progress toward development of photodynamic vaccination against infectious/malignant diseases and photodynamic mosquitocides

Kwang Poo Chang, Bala K. Kolli, Chia Kwung Fan, Dennis K.P. Ng, Clarence T.T. Wong, Laura Manna, Raffaele Corso, Neng Yao Shih, Robert Elliott, X. P. Jiang, Shin Hong Shiao, Guo Liang Fu

研究成果: 書貢獻/報告類型會議貢獻

1 引文 斯高帕斯(Scopus)

摘要

Photodynamic therapy (PDT) uses photosensitizers (PS) that are excited with light to generate ROS in the presence of oxygen for treating various diseases. PS also has the potential use as photodynamic insecticides (PDI) and for light-inactivation of Leishmania for photodynamic vaccination (PDV). PDT-inactivated Leishmania are non-viable, but remain immunologically competent as whole-cell vaccines against leishmaniasis, and as a universal carrier for delivery of add-on vaccines against other infectious and malignant diseases. We have screened novel PS, including Zn-and Si-phthalocyanines (PC) for differential PDT activities against Leishmania, insect and mammalian cells in vitro to assess their PDI and PDV potential. Here, Zn-PC were conjugated with various functional groups. The conjugates were examined for uptake by cells as a prerequisite for their susceptibility to light-inactivation. PDT sensitivity was found to vary with cell types and PS used. PDI potential of several PS was demonstrated by their mosquito larvicidal PDT activities in vitro. PDT-inactivated Leishmania were stored frozen for PDV in several ongoing studies: [1] Open label trial with 20 sick dogs for immunotherapy of canine leishmaniasis after chemotherapy in Naples, Italy. Clinical follow-up for >3 years indicate that the PDV prolongs their survival; [2] PDV of murine models with a human lung cancer vaccine showed dramatic tumor suppression; [3] Open label trial of multiple PDV via compassionate access to 4 advanced cancer patients showed no clinically adverse effects. Two subjects remain alive. Genetic modifications of Leishmania are underway to further enhance their safety and efficacy for PDV by installation of activable mechanisms for self-destruction and spontaneous light-emission.
原文英語
主出版物標題Light-Based Diagnosis and Treatment of Infectious Diseases
編輯Tianhong Dai
發行者SPIE
10479
ISBN(電子)9781510614437
DOIs
出版狀態已發佈 - 一月 1 2018
事件Light-Based Diagnosis and Treatment of Infectious Diseases 2018 - San Francisco, 美国
持續時間: 一月 29 2018一月 31 2018

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
10479
ISSN(列印)1605-7422

會議

會議Light-Based Diagnosis and Treatment of Infectious Diseases 2018
國家美国
城市San Francisco
期間1/29/181/31/18

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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    Chang, K. P., Kolli, B. K., Fan, C. K., Ng, D. K. P., Wong, C. T. T., Manna, L., Corso, R., Shih, N. Y., Elliott, R., Jiang, X. P., Shiao, S. H., & Fu, G. L. (2018). Progress toward development of photodynamic vaccination against infectious/malignant diseases and photodynamic mosquitocides. 於 T. Dai (編輯), Light-Based Diagnosis and Treatment of Infectious Diseases (卷 10479). [1047912] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; 卷 10479). SPIE. https://doi.org/10.1117/12.2281437