Prognostic value of signal transducers and activators of transcription 3 in breast cancer

Shyr Ming Sheen-Chen, Chao Cheng Huang, Rei Ping Tang, Fong Fu Chou, Hock Liew Eng

研究成果: 雜誌貢獻文章同行評審

35 引文 斯高帕斯(Scopus)

摘要

Introduction: Constitutively activated signal transducers and activators of transcription (STAT) proteins are found in varioustypes of tumors. However, there iss till very limited information about the role of STATs in breast cancer. The power of tissue microarray technique is the capability of doing a series of analyses of thousands specimens in a parallel fashion with minimal damage to the origin blocks. This study was designed with the application of tissue microarray to analyze the STAT3 status in breast cancer. Materials and Methods: Archival tissue specimens from 102 patients with primary invasive breast cancer were selected, and STAT3 expression was analyzed by immunohistochemical staining with tissue microarray. The data of primary tumor staging, age, estrogen receptor status, lymph node status, histologic grading, and tumor-node-metastasis staging were also collected. Results: By multivariate analysis, the STAT3 expression turned out to be significantly related to the overall 5-year survival rate (P = 0.024). Conclusion: Immunohistochemical staining with tissue microarray was convenient and feasible for the analysis of STAT3 expression status in breast cancer. Our preliminary results are promising and deserve further evaluation.

原文英語
頁(從 - 到)2286-2290
頁數5
期刊Cancer Epidemiology Biomarkers and Prevention
17
發行號9
DOIs
出版狀態已發佈 - 9月 1 2008
對外發佈

ASJC Scopus subject areas

  • 流行病學
  • 腫瘤科

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