Prognostic value of pretreatment CD44 mRNA in peripheral blood of patients with locally advanced head and neck cancer

Jen Tsun Lin, Tung Hao Chang, Cheng Shong Chang, Wen Hong Wang, Bi Wen Su, Kuan Der Lee, Pey Jium Chang

研究成果: 雜誌貢獻文章同行評審

20 引文 斯高帕斯(Scopus)

摘要

This study investigates the clinical significance of CD44 messenger RNA (mRNA) expression in the peripheral blood of patients with head and neck cancer. Real-time reverse transcriptase-polymerase chain reaction analysis was used to quantify CD44 mRNA levels in the peripheral blood of patients with locally advanced head and neck cancer. All patients were enrolled between January 2006 and December 2008 and had received chemotherapy/radiotherapy for their head and neck cancers. The pretreatment CD44 mRNA levels at a cutoff point of greater than fivefold were associated with an odds ratio of 12.5 for poor prognosis (95% CI, 3.9-40; p < 0.001) and could predict poor treatment response in patients with locally advanced head and neck cancers. Larger prospective studies comparing the current assay with standardized methodologies are warranted.
原文英語
期刊Oral Oncology
46
發行號5
DOIs
出版狀態已發佈 - 五月 2010
對外發佈

ASJC Scopus subject areas

  • 口腔外科
  • 腫瘤科
  • 癌症研究

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