Prognostic factors of Chinese patients with primary pulmonary non-Hodgkin's lymphoma: The single-institute experience in Taiwan

Yu Hui Hu, Liang Tsai Hsiao, Ching Fen Yang, Tzeon Jye Chiou, Jin Hwang Liu, Jyh Pyng Gau, Chueh Chuan Yen, Teh Ying Chou, Wen Hu Hsu, Po Min Chen, Cheng Hwai Tzeng

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16 引文 斯高帕斯(Scopus)

摘要

Primary pulmonary lymphoma (PPL) accounts for less than 1% of patients with non-Hodgkin's lymphoma, with no report in Chinese patients. This study aims to analyze the clinical features and prognosis of this population. Patients with biopsy-proven pulmonary lymphoma were reviewed and re-classified by a hema-pathologist. Between 1992 and 2005, a total of 22 patients were identified (16 men and six women), with a mean age of 70 years. The histological subtypes included marginal zone B-cell lymphoma of mucosa-associated lymphoid tissues (MALT) in 12 patients (54%), diffuse large B-cell lymphoma in nine (41%), and one case of lymphomatoid granulomatosis. Diseases mainly manifested as pulmonary nodules or masses in 73% of patients, with a higher rate of hilar/ mediastinal lymphadenopathy in non-MALT patients (8% vs. 80%, P = 0.002). In eight patients (36% of 22), diagnoses were only conclusive until the biopsy via thoracotomy. Eighteen patients (82%) received chemotherapy. The 5-year rates of overall survival (OS) were 91% and 21% for MALT and non-MALT types of PPL, respectively. Patients who had received surgical resection tended to have a better 5-year OS rate (P = 0.077). The Cox-regression analysis showed that two factors - elevated serum lactate dehydrogenase level and hilar/mediastinal lymphadenopathy at diagnosis - were independently associated with a poor OS, with a hazard ratio of 10.370 and 5.171 (P = 0.01 and 0.033), respectively. In conclusion, the histological subtypes of Chinese PPL patients were similar to those in previous reports, with no increasing incidence of T-cell immunophenotype. The two prognostic factors provided additional information in managing these patients.

原文英語
頁(從 - 到)839-846
頁數8
期刊Annals of Hematology
88
發行號9
DOIs
出版狀態已發佈 - 2009
對外發佈

ASJC Scopus subject areas

  • 血液學

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