摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 5642-5649 |
| 頁數 | 8 |
| 期刊 | International Journal of Clinical and Experimental Pathology |
| 卷 | 8 |
| 發行號 | 5 |
| 出版狀態 | 已發佈 - 2015 |
指紋
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
引用此文
Prognostic and predictive values of Nrf2, Keap1, p16 and E-cadherin expression in ovarian epithelial carcinoma. / Liew, Phui Ly; Hsu, Chun-Sen; Liu, Wei Min; Lee, Yu Chieh; Lee, Yi Chih; Chen, Chi Long.
於: International Journal of Clinical and Experimental Pathology, 卷 8, 編號 5, 2015, p. 5642-5649.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Prognostic and predictive values of Nrf2, Keap1, p16 and E-cadherin expression in ovarian epithelial carcinoma
AU - Liew, Phui Ly
AU - Hsu, Chun-Sen
AU - Liu, Wei Min
AU - Lee, Yu Chieh
AU - Lee, Yi Chih
AU - Chen, Chi Long
PY - 2015
Y1 - 2015
N2 - Objectives: Despite considerable interest in the Nuclear factor-erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap1), p16 and epithelial cadherin (E-cadherin) activation in carcinoma progression, contradictory results regarding association of Nrf2/Keap1/E-cadherin and p16 expression with clinico-pathological features and prognosis have been reported. The predictive value of these markers in ovarian carcinoma is unknown. Methods/Materials: In this retrospective study, 108 cases were evaluated immunohistochemically with antibodies to Nrf2, Keap1, estrogen receptor (ER), p16 and E-cadherin. The results were compared with histological and clinical data, disease-free survival (DFS) and overall survival (OS). Results: A cohort of 108 ovarian carcinomas (47 serous, 23 mucinous, 13 endometrioid and 25 clear cell), including 68 FIGO stage I-II cases and 40 FIGO stage III-IV cases was studied. The age of patients (P=0.005), FIGO stage (P
AB - Objectives: Despite considerable interest in the Nuclear factor-erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap1), p16 and epithelial cadherin (E-cadherin) activation in carcinoma progression, contradictory results regarding association of Nrf2/Keap1/E-cadherin and p16 expression with clinico-pathological features and prognosis have been reported. The predictive value of these markers in ovarian carcinoma is unknown. Methods/Materials: In this retrospective study, 108 cases were evaluated immunohistochemically with antibodies to Nrf2, Keap1, estrogen receptor (ER), p16 and E-cadherin. The results were compared with histological and clinical data, disease-free survival (DFS) and overall survival (OS). Results: A cohort of 108 ovarian carcinomas (47 serous, 23 mucinous, 13 endometrioid and 25 clear cell), including 68 FIGO stage I-II cases and 40 FIGO stage III-IV cases was studied. The age of patients (P=0.005), FIGO stage (P
KW - E-Cadherin
KW - Keap1
KW - Nrf2
KW - Ovarian cancer
KW - P16
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M3 - Article
VL - 8
SP - 5642
EP - 5649
JO - International Journal of Clinical and Experimental Pathology
JF - International Journal of Clinical and Experimental Pathology
SN - 1936-2625
IS - 5
ER -