Probing anti-proliferative 24-homoscalaranes from a sponge Lendenfeldia sp.

Bo Rong Peng, Kuei Hung Lai, You Ying Chen, Jui Hsin Su, Yusheng M. Huang, Yu Hsin Chen, Mei Chin Lu, Steve Sheng Fa Yu, Chang Yih Duh, Ping Jyun Sung

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A–D (1–4), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1–7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1–7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity.

原文英語
文章編號76
期刊Marine Drugs
18
發行號2
DOIs
出版狀態已發佈 - 一月 24 2020
對外發佈Yes

ASJC Scopus subject areas

  • Drug Discovery

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