Probabilistic assessment of aggregate risk for bisphenol A by integrating the currently available environmental data

I. Lun Hsiao, Charlene Wu, Yuh Jeen Huang, Dalaijamts Chimeddulam, Kuen Yuh Wu

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Bisphenol A (BPA) is an endocrine disruptor widely used in the production of polycarbonate plastics and epoxy resins. Exposures to BPA have been associated with reproductive, developmental, and cardiovascular effects. In this study, the CalTOX model was used to assess the aggregate health risks on BPA by integrating the currently available BPA data in various environmental media in Taiwan. Local parameters such as chemical properties, local landscape data, and exposure factors were used as model inputs under the continuous source mode. A reference dose (RfD) of 50 μg/kg-day was adopted in this assessment. Monte Carlo simulation was used to simulate great variability of the environmental data. Our results show that an upper limit of 95 % confidence interval of aggregate exposures for the adults (19–64 years old) was 1.05 μg/kg-day, corresponding to a hazard index (HI) of 0.021. The chemical properties (BPA half-life in surface water), intake rates (fruit, vegetable, and fluid intake), and landscape data (average depth of surface waters and leaf wet density) are critical parameters. Finally, HI value would approach to 1 as BPA concentrations in ambient air, surface water, and sediment was greater than 20 ng/m3, 100 μg/L, and 3.3 mg/kg. The quality of the risk assessment on BPA can be further improved by reduction of uncertainty of the abovementioned critical parameters as well as considering additional BPA exposures from canned and packaged goods.
原文英語
頁(從 - 到)1851-1861
頁數11
期刊Stochastic Environmental Research and Risk Assessment
30
發行號7
DOIs
出版狀態已發佈 - 十月 1 2016
對外發佈Yes

指紋

Surface waters
Chemical properties
Hazards
surface water
chemical property
Health risks
Vegetables
hazard
Fruits
Polycarbonates
Epoxy resins
Risk assessment
endocrine disruptor
Sediments
half life
ambient air
health risk
confidence interval
Plastics
vegetable

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Water Science and Technology
  • Safety, Risk, Reliability and Quality
  • Environmental Science(all)

引用此文

Probabilistic assessment of aggregate risk for bisphenol A by integrating the currently available environmental data. / Hsiao, I. Lun; Wu, Charlene; Huang, Yuh Jeen; Chimeddulam, Dalaijamts; Wu, Kuen Yuh.

於: Stochastic Environmental Research and Risk Assessment, 卷 30, 編號 7, 01.10.2016, p. 1851-1861.

研究成果: 雜誌貢獻文章

Hsiao, I. Lun ; Wu, Charlene ; Huang, Yuh Jeen ; Chimeddulam, Dalaijamts ; Wu, Kuen Yuh. / Probabilistic assessment of aggregate risk for bisphenol A by integrating the currently available environmental data. 於: Stochastic Environmental Research and Risk Assessment. 2016 ; 卷 30, 編號 7. 頁 1851-1861.
@article{ab37ed20bae849e4a0f3a7f311e304f9,
title = "Probabilistic assessment of aggregate risk for bisphenol A by integrating the currently available environmental data",
abstract = "Bisphenol A (BPA) is an endocrine disruptor widely used in the production of polycarbonate plastics and epoxy resins. Exposures to BPA have been associated with reproductive, developmental, and cardiovascular effects. In this study, the CalTOX model was used to assess the aggregate health risks on BPA by integrating the currently available BPA data in various environmental media in Taiwan. Local parameters such as chemical properties, local landscape data, and exposure factors were used as model inputs under the continuous source mode. A reference dose (RfD) of 50 μg/kg-day was adopted in this assessment. Monte Carlo simulation was used to simulate great variability of the environmental data. Our results show that an upper limit of 95 {\%} confidence interval of aggregate exposures for the adults (19–64 years old) was 1.05 μg/kg-day, corresponding to a hazard index (HI) of 0.021. The chemical properties (BPA half-life in surface water), intake rates (fruit, vegetable, and fluid intake), and landscape data (average depth of surface waters and leaf wet density) are critical parameters. Finally, HI value would approach to 1 as BPA concentrations in ambient air, surface water, and sediment was greater than 20 ng/m3, 100 μg/L, and 3.3 mg/kg. The quality of the risk assessment on BPA can be further improved by reduction of uncertainty of the abovementioned critical parameters as well as considering additional BPA exposures from canned and packaged goods.",
keywords = "Aggregate health risk, Bisphenol A, Monte-Carlo simulation, Multimedia model, Probabilistic assessment",
author = "Hsiao, {I. Lun} and Charlene Wu and Huang, {Yuh Jeen} and Dalaijamts Chimeddulam and Wu, {Kuen Yuh}",
year = "2016",
month = "10",
day = "1",
doi = "10.1007/s00477-015-1122-5",
language = "English",
volume = "30",
pages = "1851--1861",
journal = "Stochastic Environmental Research and Risk Assessment",
issn = "1436-3240",
publisher = "Springer New York",
number = "7",

}

TY - JOUR

T1 - Probabilistic assessment of aggregate risk for bisphenol A by integrating the currently available environmental data

AU - Hsiao, I. Lun

AU - Wu, Charlene

AU - Huang, Yuh Jeen

AU - Chimeddulam, Dalaijamts

AU - Wu, Kuen Yuh

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Bisphenol A (BPA) is an endocrine disruptor widely used in the production of polycarbonate plastics and epoxy resins. Exposures to BPA have been associated with reproductive, developmental, and cardiovascular effects. In this study, the CalTOX model was used to assess the aggregate health risks on BPA by integrating the currently available BPA data in various environmental media in Taiwan. Local parameters such as chemical properties, local landscape data, and exposure factors were used as model inputs under the continuous source mode. A reference dose (RfD) of 50 μg/kg-day was adopted in this assessment. Monte Carlo simulation was used to simulate great variability of the environmental data. Our results show that an upper limit of 95 % confidence interval of aggregate exposures for the adults (19–64 years old) was 1.05 μg/kg-day, corresponding to a hazard index (HI) of 0.021. The chemical properties (BPA half-life in surface water), intake rates (fruit, vegetable, and fluid intake), and landscape data (average depth of surface waters and leaf wet density) are critical parameters. Finally, HI value would approach to 1 as BPA concentrations in ambient air, surface water, and sediment was greater than 20 ng/m3, 100 μg/L, and 3.3 mg/kg. The quality of the risk assessment on BPA can be further improved by reduction of uncertainty of the abovementioned critical parameters as well as considering additional BPA exposures from canned and packaged goods.

AB - Bisphenol A (BPA) is an endocrine disruptor widely used in the production of polycarbonate plastics and epoxy resins. Exposures to BPA have been associated with reproductive, developmental, and cardiovascular effects. In this study, the CalTOX model was used to assess the aggregate health risks on BPA by integrating the currently available BPA data in various environmental media in Taiwan. Local parameters such as chemical properties, local landscape data, and exposure factors were used as model inputs under the continuous source mode. A reference dose (RfD) of 50 μg/kg-day was adopted in this assessment. Monte Carlo simulation was used to simulate great variability of the environmental data. Our results show that an upper limit of 95 % confidence interval of aggregate exposures for the adults (19–64 years old) was 1.05 μg/kg-day, corresponding to a hazard index (HI) of 0.021. The chemical properties (BPA half-life in surface water), intake rates (fruit, vegetable, and fluid intake), and landscape data (average depth of surface waters and leaf wet density) are critical parameters. Finally, HI value would approach to 1 as BPA concentrations in ambient air, surface water, and sediment was greater than 20 ng/m3, 100 μg/L, and 3.3 mg/kg. The quality of the risk assessment on BPA can be further improved by reduction of uncertainty of the abovementioned critical parameters as well as considering additional BPA exposures from canned and packaged goods.

KW - Aggregate health risk

KW - Bisphenol A

KW - Monte-Carlo simulation

KW - Multimedia model

KW - Probabilistic assessment

UR - http://www.scopus.com/inward/record.url?scp=84988354825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988354825&partnerID=8YFLogxK

U2 - 10.1007/s00477-015-1122-5

DO - 10.1007/s00477-015-1122-5

M3 - Article

AN - SCOPUS:84988354825

VL - 30

SP - 1851

EP - 1861

JO - Stochastic Environmental Research and Risk Assessment

JF - Stochastic Environmental Research and Risk Assessment

SN - 1436-3240

IS - 7

ER -