Primary Hepatic Malignant Fibrous Histiocytoma Mimicking Hepatocellular Carcinoma: Report of Two Cases with Immunohistochemical Detection of Ezrin, and Ultrastructural and K-ras Mutation Analysis

Phui Ly Liew, Ming Te Huang, Sey-En Lin, Hsin An Chen, Chih Hsiung Wu, Wei Hwa Lee

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

We reported two primary malignant fibrous histiocytoma (MFH) cases (cases 1 and 2) strikingly simulating hepatocellular carcinoma with immunohistochemical (IHC) stains, and ultrastructural and K-ras mutation analysis. Cases 1 and 2 both included only men, aged 65 and 72 years, respectively. Case 1 presented with abdominal pain, fever, and bilateral legs edema. Case 2 was found to have a liver tumor during routine heath examination. Computed tomography scan showed hepatic mass with fine tumor vessels. Case 1 had one 16×15×13cm 3 liver mass with tumor rupture in the right lobe, and case 2 had one 3×2.5×1cm 3 liver tumor in segment 6. Microscopically, the tumors were composed of spindle, pleomorphic, and multinucleated giant cells arranged in storiform, sheet-like, and fascicular patterns. Strong immunoreactivity for CD68 and vimentin in tumor cells in both cases was noticed. Ezrin immunoexpression in tumor tissue from case 1 was diffusely strong; in contrast, case 2 showed sparse and weak ezrin expression in tumor cells. Ultrastructurally, cells with fibroblasts and histiocytic characteristics were present in both cases. K-ras gene analysis of exon 2codon 12 or 13 showed no mutation. This is the first report describing K-ras gene analysis of liver MFH. We emphasize that ezrin immunoreactivity may be correlated with poorer prognosis.
原文英語
頁(從 - 到)183-188
頁數6
期刊Journal of Experimental and Clinical Medicine(Taiwan)
4
發行號3
DOIs
出版狀態已發佈 - 六月 2012

指紋

Malignant Fibrous Histiocytoma
Hepatocellular Carcinoma
Mutation
Liver
Neoplasms
ras Genes
ezrin
Vimentin
Giant Cells
Abdominal Pain
Rupture
Exons
Edema
Leg
Fever
Coloring Agents
Fibroblasts
Tomography

ASJC Scopus subject areas

  • Medicine(all)

引用此文

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title = "Primary Hepatic Malignant Fibrous Histiocytoma Mimicking Hepatocellular Carcinoma: Report of Two Cases with Immunohistochemical Detection of Ezrin, and Ultrastructural and K-ras Mutation Analysis",
abstract = "We reported two primary malignant fibrous histiocytoma (MFH) cases (cases 1 and 2) strikingly simulating hepatocellular carcinoma with immunohistochemical (IHC) stains, and ultrastructural and K-ras mutation analysis. Cases 1 and 2 both included only men, aged 65 and 72 years, respectively. Case 1 presented with abdominal pain, fever, and bilateral legs edema. Case 2 was found to have a liver tumor during routine heath examination. Computed tomography scan showed hepatic mass with fine tumor vessels. Case 1 had one 16×15×13cm 3 liver mass with tumor rupture in the right lobe, and case 2 had one 3×2.5×1cm 3 liver tumor in segment 6. Microscopically, the tumors were composed of spindle, pleomorphic, and multinucleated giant cells arranged in storiform, sheet-like, and fascicular patterns. Strong immunoreactivity for CD68 and vimentin in tumor cells in both cases was noticed. Ezrin immunoexpression in tumor tissue from case 1 was diffusely strong; in contrast, case 2 showed sparse and weak ezrin expression in tumor cells. Ultrastructurally, cells with fibroblasts and histiocytic characteristics were present in both cases. K-ras gene analysis of exon 2codon 12 or 13 showed no mutation. This is the first report describing K-ras gene analysis of liver MFH. We emphasize that ezrin immunoreactivity may be correlated with poorer prognosis.",
keywords = "Ezrin, K-ras mutation, Liver, Malignant fibrous histiocytoma, Ultrastructural",
author = "Liew, {Phui Ly} and Huang, {Ming Te} and Sey-En Lin and Chen, {Hsin An} and Wu, {Chih Hsiung} and Lee, {Wei Hwa}",
year = "2012",
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T1 - Primary Hepatic Malignant Fibrous Histiocytoma Mimicking Hepatocellular Carcinoma

T2 - Report of Two Cases with Immunohistochemical Detection of Ezrin, and Ultrastructural and K-ras Mutation Analysis

AU - Liew, Phui Ly

AU - Huang, Ming Te

AU - Lin, Sey-En

AU - Chen, Hsin An

AU - Wu, Chih Hsiung

AU - Lee, Wei Hwa

PY - 2012/6

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N2 - We reported two primary malignant fibrous histiocytoma (MFH) cases (cases 1 and 2) strikingly simulating hepatocellular carcinoma with immunohistochemical (IHC) stains, and ultrastructural and K-ras mutation analysis. Cases 1 and 2 both included only men, aged 65 and 72 years, respectively. Case 1 presented with abdominal pain, fever, and bilateral legs edema. Case 2 was found to have a liver tumor during routine heath examination. Computed tomography scan showed hepatic mass with fine tumor vessels. Case 1 had one 16×15×13cm 3 liver mass with tumor rupture in the right lobe, and case 2 had one 3×2.5×1cm 3 liver tumor in segment 6. Microscopically, the tumors were composed of spindle, pleomorphic, and multinucleated giant cells arranged in storiform, sheet-like, and fascicular patterns. Strong immunoreactivity for CD68 and vimentin in tumor cells in both cases was noticed. Ezrin immunoexpression in tumor tissue from case 1 was diffusely strong; in contrast, case 2 showed sparse and weak ezrin expression in tumor cells. Ultrastructurally, cells with fibroblasts and histiocytic characteristics were present in both cases. K-ras gene analysis of exon 2codon 12 or 13 showed no mutation. This is the first report describing K-ras gene analysis of liver MFH. We emphasize that ezrin immunoreactivity may be correlated with poorer prognosis.

AB - We reported two primary malignant fibrous histiocytoma (MFH) cases (cases 1 and 2) strikingly simulating hepatocellular carcinoma with immunohistochemical (IHC) stains, and ultrastructural and K-ras mutation analysis. Cases 1 and 2 both included only men, aged 65 and 72 years, respectively. Case 1 presented with abdominal pain, fever, and bilateral legs edema. Case 2 was found to have a liver tumor during routine heath examination. Computed tomography scan showed hepatic mass with fine tumor vessels. Case 1 had one 16×15×13cm 3 liver mass with tumor rupture in the right lobe, and case 2 had one 3×2.5×1cm 3 liver tumor in segment 6. Microscopically, the tumors were composed of spindle, pleomorphic, and multinucleated giant cells arranged in storiform, sheet-like, and fascicular patterns. Strong immunoreactivity for CD68 and vimentin in tumor cells in both cases was noticed. Ezrin immunoexpression in tumor tissue from case 1 was diffusely strong; in contrast, case 2 showed sparse and weak ezrin expression in tumor cells. Ultrastructurally, cells with fibroblasts and histiocytic characteristics were present in both cases. K-ras gene analysis of exon 2codon 12 or 13 showed no mutation. This is the first report describing K-ras gene analysis of liver MFH. We emphasize that ezrin immunoreactivity may be correlated with poorer prognosis.

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