Preventive use of noninvasive ventilation after extubation: A prospective, multicenter randomized controlled trial

Chien-Ling Su, Ling Ling Chiang, Shih Hsing Yang, Hen I. Lin, Kuo-Chen Cheng, Yuh Chin T Huang, Chin Pyng Wu

研究成果: 雜誌貢獻文章同行評審

64 引文 斯高帕斯(Scopus)

摘要

BACKGROUND: The effectiveness of noninvasive ventilation (NIV) after extubation in preventing post-extubation respiratory failure is still controversial. METHODS: We conducted a prospective, multicenter randomized controlled study involving patients on mechanical ventilation for>48 hours who tolerated a 2-hour spontaneous breathing trial and were subsequently extubated. The patients were randomized to NIV or standard medical therapy. Re-intubation rate within 72 hours was the primary outcome measure. Multivariable logistic regression analysis was used to determine predictors for extubation failure. RESULTS: We randomized 406 patients to either NIV (no. = 202) or standard medical therapy (no. = 204). The 2 groups had similar baseline clinical characteristics. There were no differences in extubation failure (13.2% in control and 14.9% in NIV), intensive care unit or hospital mortality. Cardiac failure was a more common cause of extubation failure in control than in NIV. There was no difference in rapid shallow breathing index (RSBI) in extubation failure patients between control (80) and NIV (73). When using data from all patients, we found Acute Physiology and Chronic Health Evaluation (APACHE II) scores (odds ratio [OR] 1.13, 95% CI 1.07-1.20, P
原文英語
頁(從 - 到)204-210
頁數7
期刊Respiratory Care
57
發行號2
DOIs
出版狀態已發佈 - 二月 2012

ASJC Scopus subject areas

  • 肺和呼吸系統醫學
  • 重症監護和重症監護醫學

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