Prevalence of metabolically healthy obesity and its impacts on incidences of hypertension, diabetes and the metabolic syndrome in Taiwan

Lee Ching Hwang, Chyi Huey Bai, Chien An Sun, Chien Jen Chen

研究成果: 雜誌貢獻文章

77 引文 (Scopus)

摘要

Obesity is an epidemic health problem related to morbidity and mortality of metabolic and cardiovascular diseases. However, little is known regarding the development of cardiometabolic diseases in an obese subgroup with a healthy metabolic risk profile. This study examined the prevalence of baseline metabolically healthy obese subjects and its impacts on the incidences of cardiometabolic diseases using a nation-wide population cohort. Metabolically healthy obese were prevalent in 8.2% of the baseline population and 28.5% of the obese subjects. Subjects included were 1,547 men and women (age range, 18-59 years), who were free of components of the metabolic syndrome except waist criteria. During an average 5.4-year follow-up, the cumulative incidences of hypertension, type 2 diabetes and the metabolic syndrome were 7.8%, 1.2% and 5.6%, respectively. The hazard ratios (95% CIs) for the metabolic syndrome incidence were significantly higher at BMI levels of ≥23.0 kg/m2 [4.68 (2.22-9.86)] for BMI of 23-24.9 kg/m2; 8.82 (4.01-19.4) for BMI of 25-26.9 kg/m2; and 24.4 (12.3-48.4) for BMI of ≥27 kg/m2). The hazard ratios for diabetes or hypertension incidence were significantly higher at BMI levels of ≥25.0 kg/m2. Each kg/m2 of BMI gained was associated with an 18% increase in the risk of developing hypertension and a 26% increase in risk for the metabolic syndrome. We conclude that metabolically healthy obese individuals are at higher risk to develop hypertension, type 2 diabetes and the metabolic syndrome than their nonobese counterparts. Our data provide further evidence that opposes the notion of metabolically healthy obese as harmless conditions.

原文英語
頁(從 - 到)227-233
頁數7
期刊Asia Pacific Journal of Clinical Nutrition
21
發行號2
出版狀態已發佈 - 六月 2012

指紋

Taiwan
Hypertension
Incidence
Type 2 Diabetes Mellitus
Metabolome
Metabolic Diseases
Population
Healthy Volunteers
Cardiovascular Diseases
Obesity
Cross-Sectional Studies
Metabolically Benign Obesity
Morbidity
Mortality
Health

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

引用此文

Prevalence of metabolically healthy obesity and its impacts on incidences of hypertension, diabetes and the metabolic syndrome in Taiwan. / Hwang, Lee Ching; Bai, Chyi Huey; Sun, Chien An; Chen, Chien Jen.

於: Asia Pacific Journal of Clinical Nutrition, 卷 21, 編號 2, 06.2012, p. 227-233.

研究成果: 雜誌貢獻文章

@article{abeb9c66b57947999042fb1d2315559f,
title = "Prevalence of metabolically healthy obesity and its impacts on incidences of hypertension, diabetes and the metabolic syndrome in Taiwan",
abstract = "Obesity is an epidemic health problem related to morbidity and mortality of metabolic and cardiovascular diseases. However, little is known regarding the development of cardiometabolic diseases in an obese subgroup with a healthy metabolic risk profile. This study examined the prevalence of baseline metabolically healthy obese subjects and its impacts on the incidences of cardiometabolic diseases using a nation-wide population cohort. Metabolically healthy obese were prevalent in 8.2{\%} of the baseline population and 28.5{\%} of the obese subjects. Subjects included were 1,547 men and women (age range, 18-59 years), who were free of components of the metabolic syndrome except waist criteria. During an average 5.4-year follow-up, the cumulative incidences of hypertension, type 2 diabetes and the metabolic syndrome were 7.8{\%}, 1.2{\%} and 5.6{\%}, respectively. The hazard ratios (95{\%} CIs) for the metabolic syndrome incidence were significantly higher at BMI levels of ≥23.0 kg/m2 [4.68 (2.22-9.86)] for BMI of 23-24.9 kg/m2; 8.82 (4.01-19.4) for BMI of 25-26.9 kg/m2; and 24.4 (12.3-48.4) for BMI of ≥27 kg/m2). The hazard ratios for diabetes or hypertension incidence were significantly higher at BMI levels of ≥25.0 kg/m2. Each kg/m2 of BMI gained was associated with an 18{\%} increase in the risk of developing hypertension and a 26{\%} increase in risk for the metabolic syndrome. We conclude that metabolically healthy obese individuals are at higher risk to develop hypertension, type 2 diabetes and the metabolic syndrome than their nonobese counterparts. Our data provide further evidence that opposes the notion of metabolically healthy obese as harmless conditions.",
keywords = "Hypertension, Incidence, Metabolically healthy obesity, The metabolic syndrome, Type 2 diabetes mellitus",
author = "Hwang, {Lee Ching} and Bai, {Chyi Huey} and Sun, {Chien An} and Chen, {Chien Jen}",
year = "2012",
month = "6",
language = "English",
volume = "21",
pages = "227--233",
journal = "Asia Pacific Journal of Clinical Nutrition",
issn = "0964-7058",
publisher = "HEC Press",
number = "2",

}

TY - JOUR

T1 - Prevalence of metabolically healthy obesity and its impacts on incidences of hypertension, diabetes and the metabolic syndrome in Taiwan

AU - Hwang, Lee Ching

AU - Bai, Chyi Huey

AU - Sun, Chien An

AU - Chen, Chien Jen

PY - 2012/6

Y1 - 2012/6

N2 - Obesity is an epidemic health problem related to morbidity and mortality of metabolic and cardiovascular diseases. However, little is known regarding the development of cardiometabolic diseases in an obese subgroup with a healthy metabolic risk profile. This study examined the prevalence of baseline metabolically healthy obese subjects and its impacts on the incidences of cardiometabolic diseases using a nation-wide population cohort. Metabolically healthy obese were prevalent in 8.2% of the baseline population and 28.5% of the obese subjects. Subjects included were 1,547 men and women (age range, 18-59 years), who were free of components of the metabolic syndrome except waist criteria. During an average 5.4-year follow-up, the cumulative incidences of hypertension, type 2 diabetes and the metabolic syndrome were 7.8%, 1.2% and 5.6%, respectively. The hazard ratios (95% CIs) for the metabolic syndrome incidence were significantly higher at BMI levels of ≥23.0 kg/m2 [4.68 (2.22-9.86)] for BMI of 23-24.9 kg/m2; 8.82 (4.01-19.4) for BMI of 25-26.9 kg/m2; and 24.4 (12.3-48.4) for BMI of ≥27 kg/m2). The hazard ratios for diabetes or hypertension incidence were significantly higher at BMI levels of ≥25.0 kg/m2. Each kg/m2 of BMI gained was associated with an 18% increase in the risk of developing hypertension and a 26% increase in risk for the metabolic syndrome. We conclude that metabolically healthy obese individuals are at higher risk to develop hypertension, type 2 diabetes and the metabolic syndrome than their nonobese counterparts. Our data provide further evidence that opposes the notion of metabolically healthy obese as harmless conditions.

AB - Obesity is an epidemic health problem related to morbidity and mortality of metabolic and cardiovascular diseases. However, little is known regarding the development of cardiometabolic diseases in an obese subgroup with a healthy metabolic risk profile. This study examined the prevalence of baseline metabolically healthy obese subjects and its impacts on the incidences of cardiometabolic diseases using a nation-wide population cohort. Metabolically healthy obese were prevalent in 8.2% of the baseline population and 28.5% of the obese subjects. Subjects included were 1,547 men and women (age range, 18-59 years), who were free of components of the metabolic syndrome except waist criteria. During an average 5.4-year follow-up, the cumulative incidences of hypertension, type 2 diabetes and the metabolic syndrome were 7.8%, 1.2% and 5.6%, respectively. The hazard ratios (95% CIs) for the metabolic syndrome incidence were significantly higher at BMI levels of ≥23.0 kg/m2 [4.68 (2.22-9.86)] for BMI of 23-24.9 kg/m2; 8.82 (4.01-19.4) for BMI of 25-26.9 kg/m2; and 24.4 (12.3-48.4) for BMI of ≥27 kg/m2). The hazard ratios for diabetes or hypertension incidence were significantly higher at BMI levels of ≥25.0 kg/m2. Each kg/m2 of BMI gained was associated with an 18% increase in the risk of developing hypertension and a 26% increase in risk for the metabolic syndrome. We conclude that metabolically healthy obese individuals are at higher risk to develop hypertension, type 2 diabetes and the metabolic syndrome than their nonobese counterparts. Our data provide further evidence that opposes the notion of metabolically healthy obese as harmless conditions.

KW - Hypertension

KW - Incidence

KW - Metabolically healthy obesity

KW - The metabolic syndrome

KW - Type 2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=84861424380&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861424380&partnerID=8YFLogxK

M3 - Article

C2 - 22507609

AN - SCOPUS:84861424380

VL - 21

SP - 227

EP - 233

JO - Asia Pacific Journal of Clinical Nutrition

JF - Asia Pacific Journal of Clinical Nutrition

SN - 0964-7058

IS - 2

ER -