Prevalence of atrial fibrillation in patients with brugada syndrome in Taiwan

Jyh Ming Jimmy Juang, Ching Yu Chen, Yen Bin Liu, Lian Yu Lin, Wen Jone Chen, Ling Ping Lai, Chia Ti Tsai, Jiunn Lee Lin

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Purpose: The aim of this study was to assess the prevalence of atrial fibrillation (AF) in patients with Brugada syndrome (BrS) and their clinical characteristics in Taiwan. Methods: The patient group consisted of 47 symptomatic BrS patients consecutively enrolled from 2000 to 2010. The definition of BrS patients with AF was a BrS patient with at least one episode of AF in a 12-lead electrogram or 24-hour holter (permanent, persistent or paroxysmal) during follow-up, or before diagnosis of BrS. Results: Six BrS patientswere identified with AF, and all of themweremale. Two experienced sudden cardiac death (SCD), 2 presented with seizure and 4 with syncope. The mean age at onset of BrS was 47 16 years, similar to those BrS patients without AF (45 14, p = 0.67). Compared to those BrS patients without AF, significantly higher percentages of the BrS patients with AF presented with seizure and documented ventricular tachyarrhythmia (p = 0.02 and 0.03, respectively). Five of them had spontaneous Brugada type I electrogram, similar to those BrS patients without AF (p = 0.9). The SCN5A mutation rate is similar between BrS patients with AF and those without AF (p = 0.69). The prevalence of AF in BrS patients in Taiwan was 12.7% (6/47, 95% confidence interval 0.06-0.19) which is not significantly lower than the 20% prevalence found in the Caucasian population (p = 0.16). Conclusions: BrS patients with AF had distinct clinical features from those patients without AF in Taiwan.
原文英語
頁(從 - 到)311-316
頁數6
期刊Acta Cardiologica Sinica
29
發行號4
出版狀態已發佈 - 七月 1 2013
對外發佈Yes

    指紋

Keywords

  • Atrial fibrillation
  • Brugada syndrome
  • Taiwan

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此

Juang, J. M. J., Chen, C. Y., Liu, Y. B., Lin, L. Y., Chen, W. J., Lai, L. P., Tsai, C. T., & Lin, J. L. (2013). Prevalence of atrial fibrillation in patients with brugada syndrome in Taiwan. Acta Cardiologica Sinica, 29(4), 311-316.