Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: A nation-wide community-based study (HALST cohort)

Jyh Ming Jimmy Juang, Ching Yu Julius Chen, Ying Hsiang Chen, I. Chien Wu, Chih Cheng Hsu, Lei Na Chen, Feng Cheng Tang, Chi Chung Wang, Chung Chou Juan, Hou Chang Chiu, Huey Ming Lo, I. Shou Chang, Juey Jen Hwang, Ling Ping Lai, Fu Tien Chiang, Jiunn-Lee Lin, Chao Agnes Hsiung

研究成果: 雜誌貢獻文章

14 引文 (Scopus)

摘要

Aims The exact world-wide prevalence of Brugada electrocardiogram (ECG) pattern is still unclear, especially in adults aged 55 years and older. Methods and results The study was conducted as part of the Healthy Aging Longitudinal Study in Taiwan (HALST). Using a stratified random sampled method, a sample of community-dwelling subjects was recruited from seven community-based regions across Taiwan. All enrolled subjects were follow-up annually and cause of death was documented by citizen death records. A total of 5214 subjects were enrolled (male/female: 2530/2684) with a mean age of 69 ± 8 years. The overall prevalence of Brugada ECG patterns was 3.32%. Four subjects carried spontaneous Type 1 Brugada ECG pattern, 68 carried Type 2, and 101 carried Type 3. Compared with the world-wide average prevalence of Brugada ECG patterns, the prevalence of spontaneous Type 1 Brugada ECG pattern in subjects from the HALST cohort was similar (0.077 vs. 0.07%) and the combined prevalence of Types 2 and 3 Brugada ECG pattern was 10 times higher (3.24 vs. 0.28%) even the mean age of study subjects was significantly higher (69 ± 8 vs. 35 ± 8, P < 0.001). However, all-cause mortality and cardiac mortality rates were not significantly different between subjects with and without Brugada ECG patterns during the 4-year follow-up (log-rank test, P = 0.21, 0.32, respectively). Conclusion The prevalence of Brugada ECG pattern in adults aged 55 years and older in Taiwan was higher than the average world-wide prevalence but was not associated with increased mortality.

原文英語
頁(從 - 到)ii54-ii62
期刊Europace
17
DOIs
出版狀態已發佈 - 二月 28 2015
對外發佈Yes

指紋

Taiwan
Longitudinal Studies
Electrocardiography
Population
Mortality
Independent Living
Death Certificates
Cause of Death
Healthy Volunteers

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

引用此文

Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population : A nation-wide community-based study (HALST cohort). / Juang, Jyh Ming Jimmy; Chen, Ching Yu Julius; Chen, Ying Hsiang; Wu, I. Chien; Hsu, Chih Cheng; Chen, Lei Na; Tang, Feng Cheng; Wang, Chi Chung; Juan, Chung Chou; Chiu, Hou Chang; Lo, Huey Ming; Chang, I. Shou; Hwang, Juey Jen; Lai, Ling Ping; Chiang, Fu Tien; Lin, Jiunn-Lee; Hsiung, Chao Agnes.

於: Europace, 卷 17, 28.02.2015, p. ii54-ii62.

研究成果: 雜誌貢獻文章

Juang, JMJ, Chen, CYJ, Chen, YH, Wu, IC, Hsu, CC, Chen, LN, Tang, FC, Wang, CC, Juan, CC, Chiu, HC, Lo, HM, Chang, IS, Hwang, JJ, Lai, LP, Chiang, FT, Lin, J-L & Hsiung, CA 2015, 'Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: A nation-wide community-based study (HALST cohort)', Europace, 卷 17, 頁 ii54-ii62. https://doi.org/10.1093/europace/euv141
Juang, Jyh Ming Jimmy ; Chen, Ching Yu Julius ; Chen, Ying Hsiang ; Wu, I. Chien ; Hsu, Chih Cheng ; Chen, Lei Na ; Tang, Feng Cheng ; Wang, Chi Chung ; Juan, Chung Chou ; Chiu, Hou Chang ; Lo, Huey Ming ; Chang, I. Shou ; Hwang, Juey Jen ; Lai, Ling Ping ; Chiang, Fu Tien ; Lin, Jiunn-Lee ; Hsiung, Chao Agnes. / Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population : A nation-wide community-based study (HALST cohort). 於: Europace. 2015 ; 卷 17. 頁 ii54-ii62.
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title = "Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: A nation-wide community-based study (HALST cohort)",
abstract = "Aims The exact world-wide prevalence of Brugada electrocardiogram (ECG) pattern is still unclear, especially in adults aged 55 years and older. Methods and results The study was conducted as part of the Healthy Aging Longitudinal Study in Taiwan (HALST). Using a stratified random sampled method, a sample of community-dwelling subjects was recruited from seven community-based regions across Taiwan. All enrolled subjects were follow-up annually and cause of death was documented by citizen death records. A total of 5214 subjects were enrolled (male/female: 2530/2684) with a mean age of 69 ± 8 years. The overall prevalence of Brugada ECG patterns was 3.32{\%}. Four subjects carried spontaneous Type 1 Brugada ECG pattern, 68 carried Type 2, and 101 carried Type 3. Compared with the world-wide average prevalence of Brugada ECG patterns, the prevalence of spontaneous Type 1 Brugada ECG pattern in subjects from the HALST cohort was similar (0.077 vs. 0.07{\%}) and the combined prevalence of Types 2 and 3 Brugada ECG pattern was 10 times higher (3.24 vs. 0.28{\%}) even the mean age of study subjects was significantly higher (69 ± 8 vs. 35 ± 8, P < 0.001). However, all-cause mortality and cardiac mortality rates were not significantly different between subjects with and without Brugada ECG patterns during the 4-year follow-up (log-rank test, P = 0.21, 0.32, respectively). Conclusion The prevalence of Brugada ECG pattern in adults aged 55 years and older in Taiwan was higher than the average world-wide prevalence but was not associated with increased mortality.",
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author = "Juang, {Jyh Ming Jimmy} and Chen, {Ching Yu Julius} and Chen, {Ying Hsiang} and Wu, {I. Chien} and Hsu, {Chih Cheng} and Chen, {Lei Na} and Tang, {Feng Cheng} and Wang, {Chi Chung} and Juan, {Chung Chou} and Chiu, {Hou Chang} and Lo, {Huey Ming} and Chang, {I. Shou} and Hwang, {Juey Jen} and Lai, {Ling Ping} and Chiang, {Fu Tien} and Jiunn-Lee Lin and Hsiung, {Chao Agnes}",
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pages = "ii54--ii62",
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T1 - Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population

T2 - A nation-wide community-based study (HALST cohort)

AU - Juang, Jyh Ming Jimmy

AU - Chen, Ching Yu Julius

AU - Chen, Ying Hsiang

AU - Wu, I. Chien

AU - Hsu, Chih Cheng

AU - Chen, Lei Na

AU - Tang, Feng Cheng

AU - Wang, Chi Chung

AU - Juan, Chung Chou

AU - Chiu, Hou Chang

AU - Lo, Huey Ming

AU - Chang, I. Shou

AU - Hwang, Juey Jen

AU - Lai, Ling Ping

AU - Chiang, Fu Tien

AU - Lin, Jiunn-Lee

AU - Hsiung, Chao Agnes

PY - 2015/2/28

Y1 - 2015/2/28

N2 - Aims The exact world-wide prevalence of Brugada electrocardiogram (ECG) pattern is still unclear, especially in adults aged 55 years and older. Methods and results The study was conducted as part of the Healthy Aging Longitudinal Study in Taiwan (HALST). Using a stratified random sampled method, a sample of community-dwelling subjects was recruited from seven community-based regions across Taiwan. All enrolled subjects were follow-up annually and cause of death was documented by citizen death records. A total of 5214 subjects were enrolled (male/female: 2530/2684) with a mean age of 69 ± 8 years. The overall prevalence of Brugada ECG patterns was 3.32%. Four subjects carried spontaneous Type 1 Brugada ECG pattern, 68 carried Type 2, and 101 carried Type 3. Compared with the world-wide average prevalence of Brugada ECG patterns, the prevalence of spontaneous Type 1 Brugada ECG pattern in subjects from the HALST cohort was similar (0.077 vs. 0.07%) and the combined prevalence of Types 2 and 3 Brugada ECG pattern was 10 times higher (3.24 vs. 0.28%) even the mean age of study subjects was significantly higher (69 ± 8 vs. 35 ± 8, P < 0.001). However, all-cause mortality and cardiac mortality rates were not significantly different between subjects with and without Brugada ECG patterns during the 4-year follow-up (log-rank test, P = 0.21, 0.32, respectively). Conclusion The prevalence of Brugada ECG pattern in adults aged 55 years and older in Taiwan was higher than the average world-wide prevalence but was not associated with increased mortality.

AB - Aims The exact world-wide prevalence of Brugada electrocardiogram (ECG) pattern is still unclear, especially in adults aged 55 years and older. Methods and results The study was conducted as part of the Healthy Aging Longitudinal Study in Taiwan (HALST). Using a stratified random sampled method, a sample of community-dwelling subjects was recruited from seven community-based regions across Taiwan. All enrolled subjects were follow-up annually and cause of death was documented by citizen death records. A total of 5214 subjects were enrolled (male/female: 2530/2684) with a mean age of 69 ± 8 years. The overall prevalence of Brugada ECG patterns was 3.32%. Four subjects carried spontaneous Type 1 Brugada ECG pattern, 68 carried Type 2, and 101 carried Type 3. Compared with the world-wide average prevalence of Brugada ECG patterns, the prevalence of spontaneous Type 1 Brugada ECG pattern in subjects from the HALST cohort was similar (0.077 vs. 0.07%) and the combined prevalence of Types 2 and 3 Brugada ECG pattern was 10 times higher (3.24 vs. 0.28%) even the mean age of study subjects was significantly higher (69 ± 8 vs. 35 ± 8, P < 0.001). However, all-cause mortality and cardiac mortality rates were not significantly different between subjects with and without Brugada ECG patterns during the 4-year follow-up (log-rank test, P = 0.21, 0.32, respectively). Conclusion The prevalence of Brugada ECG pattern in adults aged 55 years and older in Taiwan was higher than the average world-wide prevalence but was not associated with increased mortality.

KW - Brugada ECG pattern

KW - Community-based

KW - Han Chinese population

KW - Long-term prognosis

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