Presence of conspecifics and their odor-impregnated objects reverse stress-decreased neurogenesis in mouse dentate gyrus

Chianfang G. Cherng, Pei Syuan Lin, Jia Ying Chuang, Wan Ting Chang, Yung Shuan Lee, Gour Shenq Kao, Yu Ting Lai, Lung Yu

研究成果: 雜誌貢獻文章

17 引文 (Scopus)

摘要

Stress and corticosterone level are thought to negatively associate with neurogenesis in mammalian brains. Social support can diminish many adverse effects of stress. The present study examined the modulating effect of social support on stress-decreased cell proliferation and neuronal differentiation in a mouse model. A randomly-scheduled foot shock followed by restraint in water was used as a profound stress-provoking regimen. Bromodeoxyuridine (BrdU) staining was used to indicate newly mitotic cells and doublecortin (DCx) staining was used to reveal immature neurons. This stress-provoking regimen rapidly decreased BrdU- and BrdU/DCx-labeled cells in the dentate gyrus. However, such a stress-provoking regimen did not affect the number of these labeled cells in the subventricular zone. Familiar and unfamiliar mice' company throughout the stress regimen completely reversed the stress-decreased cell proliferation and neuronal genesis in the dentate gyrus. Likewise, both odor-familiar (from their home cages) and -unfamiliar (from cages other than their home cages) wooden blocks completely reversed the stress-decreased BrdU/DCx-labeled cells in the dentate gyrus. In contrast, wooden blocks free of any odor and camphor odor alone failed to affect the stress-decreased BrdU- or BrdU/DCx-labeled cells. Finally, we showed that conspecifics or their odors during the stress regimen reversed the stress-decreased cell proliferation and neuronal differentiation in the dentate gyrus via a corticosterone-independent mechanism. We conclude that stress and familiarity distinctively affect neurogenesis in the dentate gyrus and subventricular zone. Conspecific companions or presence of their odors reverse stress-decreased neurogenesis in the dentate gyrus, suggesting that social support during stress exposure may improve neurogenesis-related psychological functions.
原文英語
頁(從 - 到)1138-1146
頁數9
期刊Journal of Neurochemistry
112
發行號5
DOIs
出版狀態已發佈 - 三月 2010
對外發佈Yes

指紋

Neurogenesis
Dentate Gyrus
Odors
Bromodeoxyuridine
Social Support
Lateral Ventricles
Cell Proliferation
Corticosterone
Staining and Labeling
Camphor
Cell proliferation
Odorants
Foot
Shock
Cell Count
Psychology
Neurons
Water
Brain

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

引用此文

Presence of conspecifics and their odor-impregnated objects reverse stress-decreased neurogenesis in mouse dentate gyrus. / Cherng, Chianfang G.; Lin, Pei Syuan; Chuang, Jia Ying; Chang, Wan Ting; Lee, Yung Shuan; Kao, Gour Shenq; Lai, Yu Ting; Yu, Lung.

於: Journal of Neurochemistry, 卷 112, 編號 5, 03.2010, p. 1138-1146.

研究成果: 雜誌貢獻文章

Cherng, Chianfang G. ; Lin, Pei Syuan ; Chuang, Jia Ying ; Chang, Wan Ting ; Lee, Yung Shuan ; Kao, Gour Shenq ; Lai, Yu Ting ; Yu, Lung. / Presence of conspecifics and their odor-impregnated objects reverse stress-decreased neurogenesis in mouse dentate gyrus. 於: Journal of Neurochemistry. 2010 ; 卷 112, 編號 5. 頁 1138-1146.
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abstract = "Stress and corticosterone level are thought to negatively associate with neurogenesis in mammalian brains. Social support can diminish many adverse effects of stress. The present study examined the modulating effect of social support on stress-decreased cell proliferation and neuronal differentiation in a mouse model. A randomly-scheduled foot shock followed by restraint in water was used as a profound stress-provoking regimen. Bromodeoxyuridine (BrdU) staining was used to indicate newly mitotic cells and doublecortin (DCx) staining was used to reveal immature neurons. This stress-provoking regimen rapidly decreased BrdU- and BrdU/DCx-labeled cells in the dentate gyrus. However, such a stress-provoking regimen did not affect the number of these labeled cells in the subventricular zone. Familiar and unfamiliar mice' company throughout the stress regimen completely reversed the stress-decreased cell proliferation and neuronal genesis in the dentate gyrus. Likewise, both odor-familiar (from their home cages) and -unfamiliar (from cages other than their home cages) wooden blocks completely reversed the stress-decreased BrdU/DCx-labeled cells in the dentate gyrus. In contrast, wooden blocks free of any odor and camphor odor alone failed to affect the stress-decreased BrdU- or BrdU/DCx-labeled cells. Finally, we showed that conspecifics or their odors during the stress regimen reversed the stress-decreased cell proliferation and neuronal differentiation in the dentate gyrus via a corticosterone-independent mechanism. We conclude that stress and familiarity distinctively affect neurogenesis in the dentate gyrus and subventricular zone. Conspecific companions or presence of their odors reverse stress-decreased neurogenesis in the dentate gyrus, suggesting that social support during stress exposure may improve neurogenesis-related psychological functions.",
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AU - Chang, Wan Ting

AU - Lee, Yung Shuan

AU - Kao, Gour Shenq

AU - Lai, Yu Ting

AU - Yu, Lung

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