Preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs

Hsiu O. Ho, Chih Chuan Hsiao, Ming Thau Sheu

研究成果: 雜誌貢獻文章同行評審

103 引文 斯高帕斯(Scopus)

摘要

Phase diagrams containing the microemulsion region were constructed for pseudo-ternary systems composed of polyglycerol tarry acid ester/cosurfactant/Captex 300/water. It was found necessary to add ethanol, 1-propanol, or 1-butanol as cosurfactant to produce microemulsions. The results also demonstrated microemulsions were only able to form when employing polyglycerol fatty acid esters with hydrophilelipophile balances (HLBs) between 8 and 13, such as MO500, MO750, SO750, and ML310. Most microemulsions were determined to be Winsor type IV by dilution and dye solubility tests. Microemulsions stored at ambient temperature maintained constant viscosity, indicating that the system was thermodynamically stable for long periods. Further, several microemulsion formulations were demonstrated to be promising for oral delivery of insulin based on the results of stability tests and acid-protection efficiency.

原文英語
頁(從 - 到)138-143
頁數6
期刊Journal of Pharmaceutical Sciences
85
發行號2
DOIs
出版狀態已發佈 - 2月 1996

ASJC Scopus subject areas

  • 藥物發現
  • 有機化學
  • 化學 (全部)
  • 分子醫學
  • 藥理
  • 藥學科學

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