Preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs

Hsiu O. Ho, Chih Chuan Hsiao, Ming Thau Sheu

研究成果: 雜誌貢獻文章

100 引文 (Scopus)

摘要

Phase diagrams containing the microemulsion region were constructed for pseudo-ternary systems composed of polyglycerol tarry acid ester/cosurfactant/Captex 300/water. It was found necessary to add ethanol, 1-propanol, or 1-butanol as cosurfactant to produce microemulsions. The results also demonstrated microemulsions were only able to form when employing polyglycerol fatty acid esters with hydrophilelipophile balances (HLBs) between 8 and 13, such as MO500, MO750, SO750, and ML310. Most microemulsions were determined to be Winsor type IV by dilution and dye solubility tests. Microemulsions stored at ambient temperature maintained constant viscosity, indicating that the system was thermodynamically stable for long periods. Further, several microemulsion formulations were demonstrated to be promising for oral delivery of insulin based on the results of stability tests and acid-protection efficiency.

原文英語
頁(從 - 到)138-143
頁數6
期刊Journal of Pharmaceutical Sciences
85
發行號2
DOIs
出版狀態已發佈 - 二月 1996

指紋

Microemulsions
Surface-Active Agents
Esters
Fatty Acids
1-Propanol
1-Butanol
Acids
Viscosity
Pharmaceutical Preparations
Solubility
Proteins
Ethanol
Coloring Agents
Insulin
Temperature
Water
Ternary systems
Dilution
Phase diagrams
polyglycerol

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

引用此文

@article{39e4d881f92945c7947c355850a1caa4,
title = "Preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs",
abstract = "Phase diagrams containing the microemulsion region were constructed for pseudo-ternary systems composed of polyglycerol tarry acid ester/cosurfactant/Captex 300/water. It was found necessary to add ethanol, 1-propanol, or 1-butanol as cosurfactant to produce microemulsions. The results also demonstrated microemulsions were only able to form when employing polyglycerol fatty acid esters with hydrophilelipophile balances (HLBs) between 8 and 13, such as MO500, MO750, SO750, and ML310. Most microemulsions were determined to be Winsor type IV by dilution and dye solubility tests. Microemulsions stored at ambient temperature maintained constant viscosity, indicating that the system was thermodynamically stable for long periods. Further, several microemulsion formulations were demonstrated to be promising for oral delivery of insulin based on the results of stability tests and acid-protection efficiency.",
author = "Ho, {Hsiu O.} and Hsiao, {Chih Chuan} and Sheu, {Ming Thau}",
year = "1996",
month = "2",
doi = "10.1021/js950352h",
language = "English",
volume = "85",
pages = "138--143",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs

AU - Ho, Hsiu O.

AU - Hsiao, Chih Chuan

AU - Sheu, Ming Thau

PY - 1996/2

Y1 - 1996/2

N2 - Phase diagrams containing the microemulsion region were constructed for pseudo-ternary systems composed of polyglycerol tarry acid ester/cosurfactant/Captex 300/water. It was found necessary to add ethanol, 1-propanol, or 1-butanol as cosurfactant to produce microemulsions. The results also demonstrated microemulsions were only able to form when employing polyglycerol fatty acid esters with hydrophilelipophile balances (HLBs) between 8 and 13, such as MO500, MO750, SO750, and ML310. Most microemulsions were determined to be Winsor type IV by dilution and dye solubility tests. Microemulsions stored at ambient temperature maintained constant viscosity, indicating that the system was thermodynamically stable for long periods. Further, several microemulsion formulations were demonstrated to be promising for oral delivery of insulin based on the results of stability tests and acid-protection efficiency.

AB - Phase diagrams containing the microemulsion region were constructed for pseudo-ternary systems composed of polyglycerol tarry acid ester/cosurfactant/Captex 300/water. It was found necessary to add ethanol, 1-propanol, or 1-butanol as cosurfactant to produce microemulsions. The results also demonstrated microemulsions were only able to form when employing polyglycerol fatty acid esters with hydrophilelipophile balances (HLBs) between 8 and 13, such as MO500, MO750, SO750, and ML310. Most microemulsions were determined to be Winsor type IV by dilution and dye solubility tests. Microemulsions stored at ambient temperature maintained constant viscosity, indicating that the system was thermodynamically stable for long periods. Further, several microemulsion formulations were demonstrated to be promising for oral delivery of insulin based on the results of stability tests and acid-protection efficiency.

UR - http://www.scopus.com/inward/record.url?scp=0030038207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030038207&partnerID=8YFLogxK

U2 - 10.1021/js950352h

DO - 10.1021/js950352h

M3 - Article

C2 - 8683437

AN - SCOPUS:0030038207

VL - 85

SP - 138

EP - 143

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 2

ER -