Preparation of fucoidan-shelled and genipin-crosslinked chitosan beads for antibacterial application

Shu Huei Yu, Shao Jung Wu, Jui Yu Wu, De Yu Wen, Fwu Long Mi

研究成果: 雜誌貢獻文章同行評審

56 引文 斯高帕斯(Scopus)

摘要

In this study, a fucoidan-shelled chitosan bead was developed with the purpose of oral delivery of berberine to inhibit the growth of bacteria. The cross-linking level and swelling property of the beads were affected by the pH value and the composition of the genipin/fucoidan combined gelling agent. The drug release of the berberine-loaded beads was faster in simulated gastric fluid (pH 1.2) than those in simulated intestinal fluid (pH 7.4). Furthermore, a nanoparticles/beads complex system was developed by incorporation of berberine-loaded chitosan/fucoidan nanoparticles in the fucoidan-shelled chitosan beads. The nanoparticles/beads complex served as a drug carrier to delay the berberine release in simulated gastric fluid, with an estimated lag time of 2 h. Our results showed that the berberine-loaded beads and nanoparticles/beads complex could effectively inhibit the growth inhibition of common clinical pathogens, such as Staphylococcus aureus and Escherichia coli, and have the advantage of continually releasing berberine to inhibit the growth of the bacteria over 24 h.

原文英語
頁(從 - 到)97-107
頁數11
期刊Carbohydrate Polymers
126
DOIs
出版狀態已發佈 - 八月 1 2015

ASJC Scopus subject areas

  • 有機化學
  • 聚合物和塑料
  • 材料化學

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