Preparation of Calcium Phosphate Compounds on Zirconia Surfaces for Dental Implant Applications

Mei Shuan Cheng, Eisner Salamanca, Jerry Chin Yi Lin, Yu Hwa Pan, Yi Fan Wu, Nai Chia Teng, Ikki Watanabe, Ying Sui Sun, Wei Jen Chang

研究成果: 雜誌貢獻文章同行評審


Titanium is widely used in medical implants despite the release of heavy metal ions over long-term use. Zirconia is very close to the color of teeth; however, its biological inertness hinders bonding with bone tissue. Alkaline treatment and coatings of calcium phosphate can be used to enhance bone regeneration adjacent to dental implants. This study examined the effects of alkaline treatment, calcium phosphate coatings, and sintering, on the physical properties of implant material. Our analysis confirmed that the calcium phosphate species were octacalcium phosphate (OCP). The sintering of calcium phosphate was shown to create B-type HAP, which is highly conducive toward the differentiation of mesenchymal stem cells (MSCs) into osteoblasts for the facilitation of bone integration. Conclusions: This study demonstrated the room-temperature fabrication of dental implants with superhydrophilic surfaces to enhance biocompatibility.
期刊International journal of molecular sciences
出版狀態已發佈 - 6月 1 2022

ASJC Scopus subject areas

  • 催化
  • 分子生物學
  • 光譜
  • 電腦科學應用
  • 物理與理論化學
  • 有機化學
  • 無機化學


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