Preparation of a biofunctionalized surface on titanium for biomedical applications: Surface properties, wettability variations, and biocompatibility characteristics

Mao Suan Huang, Chia Yu Wu, Keng Liang Ou, Bai Hung Huang, Tien Hsin Chang, Kazuhiko Endo, Yung Chieh Cho, Hsing Yu Lin, C. M. Liu

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

This study developed a promising approach (low-temperature plasma polymerization with allylamine) to modify the titanium (Ti) surface, which helps the damaged tissue to heal faster. The Ti surface was first cleaned by argon (Ar) plasma, and then the functional amino-groups were coated on the Ti surface via plasma polymerization. The topography characteristics, wettability, and optimal plasma modification parameters were investigated through atomic force spectroscopy, secondary ion mass spectroscopy, and response surface methodology (RSM). Analytical results showed that the formation of a porous surface was found on the Ar plasma-modified Ti surfaces after Ar plasma modification with different parameters. The Ar plasma modification is an effective approach to remove surface contaminants and generate a porous topography on the Ti surface. As the Ti with Ar plasma modification was at 100 W and 190 m Torr for 12 min, the surface exhibited the maximum hydrophilic performance. In the allylamine plasma modifications, the contact angle values of the allylamine plasma-modified Ti surfaces varied between 70.15° and 88.26° in the designed parameters. The maximum concentration of amino-groups (31.58 nmole/cm2) can be obtained from the plasma-polymerized sample at 80 W and 150 mTorr for 22 min. Moreover, the cell response also demonstrated that the allylamine plasma-modified Ti sample with an optimal modification parameter (80W, 22 min, and 150 mTorr) possessed great potential to increase cell adhesion ability. Thus, the optimal parameters of the low-temperature plasma polymerization with allylamine can be harvested using the RSM design. These data could provide new scientific information in the surface modification of Ti implant.
原文英語
文章編號1438
期刊Applied Sciences (Switzerland)
10
發行號4
DOIs
出版狀態已發佈 - 二月 1 2020

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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