Preparation of 6-phenyl- and 8-phenyl tetrahydroisoquinolines from boldine

Wei J. Huang, Chung Hsiung Chen, Shoei Sheng Lee

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Four 6-phenyl- and 8-phenyltetrahydroisoquinolines were prepared by structural modifications of boldine nucleus. These involved four major reaction steps, including solvolysis of 2-hydroxyaporphine, ozonolysis of the C-9, 10 double bond of phenanthrene nucleus leading to the key intermediate, and final Pictet-Spengler cyclization to respective target products.

原文英語
頁(從 - 到)1573-1588
頁數16
期刊Heterocycles
60
發行號7
出版狀態已發佈 - 七月 1 2003
對外發佈Yes

ASJC Scopus subject areas

  • Organic Chemistry

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