Preparation and release properties of biodegradable chitin microcapsules: I. Preparation of 6-mercaptopurine microcapsules by phase separation methods

F. L. Mi, Y. C. Tseng, C. T. Chen, S. S. Shyu

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Chitin [poly-(N-acetyl-1,4-β-D-glucopyranosamine)] microcapsules were prepared by the simple desolvation and the non-solvent addition phase separation methods. In the simple desolvation method, chitin droplets were dropped into the desolvation agent (water, ethanol, or acetone) and microcapsules soon formed. Several solvent-nonsolvent pairs: N,N-dimethylacetamide (DMAc)water, DMAc-ethanol, DMAc-n-propanol, DMAc-n-butanol, and DMAc-acetone with different solubility parameter difference, (Δδ) were chosen to prepare chitin microcapsules containing 6-mercaptopurine by using the nonsolvent-addition phase separation method. The results showed that the surface morphology and release behaviour of the microcapsules were greatly affected by different solvent-nonsolvent pairs. The surface of the microcapsules prepared from the system of high Δδ was more smooth than those from the systems of low Δδ. The drug content using the simple desolvation method increased with decreasing Δδ because of the higher film formation rate of the microcapsules. On the other hand, the drug content using the nonsolvent addition method was lower than that using the simple desolvation method because of the dispersion forces, applied by mechanical stirring. Microcapsules prepared by the simple desolvation method had a narrower size distribution and larger mean size than those prepared by the nonsolvent addition method.

原文英語
頁(從 - 到)15-25
頁數11
期刊Journal of Microencapsulation
14
發行號1
出版狀態已發佈 - 一月 1997
對外發佈

ASJC Scopus subject areas

  • 化學(雜項)
  • 藥學科學
  • 化學工程 (全部)
  • 藥理

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