Preparation and characterization of radical and pH-responsive chitosan-gallic acid conjugate drug carriers

Shu Huei Yu, Fwu Long Mi, Jen Chieh Pang, Shun Chou Jiang, T. H. Kuo, Shao Jung Wu, Shing Shin Shyu

研究成果: 雜誌貢獻文章同行評審

59 引文 斯高帕斯(Scopus)

摘要

A novel chitosan-based nanoparticle carrier was prepared in this study. The chitosan derivative, N,O-carboxymethylchitosan (NOCC) was reacted with gallic acid (GA) using a non-toxic water-soluble carbodiimide to obtain the NOCC-GA conjugate, and the chemical structure of the conjugate was characterized with FT-IR and NMR spectra. The antioxidant activity of the NOCC-GA conjugate was examined by DPPH and ABTS+ radical scavenging activity. The radical/pH-responsive properties of the NOCC-GA conjugate and its iron(II) complex were examined by fluorescence spectral and light transmittance studies. The mean particle sizes of the NOCC-GA conjugate and its iron(II) complex nanoparticles were determined by a light scattering method. The NOCC-GA conjugate and its iron(II) complex nanoparticles might provide a novel way to deliver antioxidative protein or natural products in future.

原文英語
頁(從 - 到)794-802
頁數9
期刊Carbohydrate Polymers
84
發行號2
DOIs
出版狀態已發佈 - 三月 1 2011
對外發佈Yes

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

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