Preparation and characterization of ion-irradiated nanodiamonds as photoacoustic contrast agents

Chia Yi Fang, Cheng Chun Chang, Chung Yuan Mou, Huan Cheng Chang

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

Highly radiation-damaged or irradiated nanodiamonds (INDs) are a new type of nanomaterial developed recently as a potential photoacoustic (PA) contrast agent for deep-tissue imaging. This work characterized in detail the photophysical properties of these materials prepared by ion irradiation of natural diamond powders using various spectroscopic methods. For 40-nm NDs irradiated with 40-keV He+ at a dose of 3 × 1015 ions/cm2, an average molar extinction coefficient of 4.2 M-1 cm-1 per carbon atom was measured at 1064 nm. Compared with gold nanorods of similar dimensions (10 nm x 67 nm), the INDs have a substantially smaller (by > 4 orders of magnitude) molar extinction coefficient per particle. However, the deficit is readily compensated by the much higher thermal stability, stronger hydrophilic interaction with water, and a lower nanobubble formation threshold (∼30 mJ/cm2) of the sp3-carbon-based nanomaterial. No sign of photodamage was detected after high-energy (> 100 mJ/cm2) illumination of the INDs for hours. Cell viability assays at the IND concentration of up to 100 μg/mL showed that the nanomaterial is non-cytotoxic and potentially useful for long-term PA bioimaging applications.

原文英語
頁(從 - 到)1037-1044
頁數8
期刊Journal of Nanoscience and Nanotechnology
15
發行號2
DOIs
出版狀態已發佈 - 2月 1 2015
對外發佈

ASJC Scopus subject areas

  • 生物工程
  • 化學 (全部)
  • 生物醫學工程
  • 材料科學(全部)
  • 凝聚態物理學

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