Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs

Su Lin Lee, Wei Jan Huang, Wan-Wan Lin, Shoei Sheng Lee, Chung Hsiung Chen

研究成果: 雜誌貢獻文章同行評審

70 引文 斯高帕斯(Scopus)

摘要

Seven diarylheptylamine (12a-g) and four diarylheptanoid analogs (3-5, 9), structurally related to the natural anti-inflammatory agent oregonin (1), have been prepared from curcumin (2) for evaluation of their activity against the expression of iNOS and COX-2. Diarylheptylamine 12b and diarylheptanoid analogs can inhibit iNOS and COX-2 responses of LPS, although less potently than 1. These compounds, however, possess stronger potency than 1 against COX-2-derived PGE2 formation, of which hexahydrocurcumin (4) is the most potent one with an IC50 value of 0.7 μM.

原文英語
頁(從 - 到)6175-6181
頁數7
期刊Bioorganic and Medicinal Chemistry
13
發行號22
DOIs
出版狀態已發佈 - 十一月 15 2005
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

指紋

深入研究「Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs」主題。共同形成了獨特的指紋。

引用此