Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs

Su Lin Lee, Wei Jan Huang, Wan Wan Lin, Shoei Sheng Lee, Chung Hsiung Chen

研究成果: 雜誌貢獻文章

66 引文 斯高帕斯(Scopus)

摘要

Seven diarylheptylamine (12a-g) and four diarylheptanoid analogs (3-5, 9), structurally related to the natural anti-inflammatory agent oregonin (1), have been prepared from curcumin (2) for evaluation of their activity against the expression of iNOS and COX-2. Diarylheptylamine 12b and diarylheptanoid analogs can inhibit iNOS and COX-2 responses of LPS, although less potently than 1. These compounds, however, possess stronger potency than 1 against COX-2-derived PGE2 formation, of which hexahydrocurcumin (4) is the most potent one with an IC50 value of 0.7 μM.

原文英語
頁(從 - 到)6175-6181
頁數7
期刊Bioorganic and Medicinal Chemistry
13
發行號22
DOIs
出版狀態已發佈 - 十一月 15 2005
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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