Preliminary results: Colorectal cancer screening using fecal immunochemical test (FIT) in a Thai population aged 45-74 years: A population-based randomized controlled trial

Pongdech Sarakarn, Supannee Promthet, Patravoot Vatanasapt, Nakhon Tipsunthonsak, Kriangsak Jenwitheesuk, Naowarat Maneenin, Chananya Jirapornkul, Siriporn Kamsa-Ard, Tiptiya Haengsorn, Channarong Arkkhaboot, Sam Li Sheng Chen, Amy Ming Fang Yen, Sherry Yueh Hsia Chiu, Jean Ching Yuan Fann, Tony Hsiu Hsi Chen

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

摘要

Objective: The aim of this paper is to provide some details and the results to date of a colorectal cancer screening trial using a fecal immunochemical test (FIT). Methods: A population-based randomized controlled trial began in May, 2016. All people aged 45 to 74 years living in Nam Phong District, Khon Kaen Province, Thailand, and willing to participate are being recruited using an outreach method. Enrolled participants are randomly allocated by a computer-generated randomization program either to a study arm (receive sample kit for FIT) or to a control arm (no provision of kit). Positive FIT cases are subsequently confirmed by a colonoscopy examination, and negative FIT cases are re-tested with FIT every two years. The preliminary results to date were analysed using descriptive statistics. Results: A total of 1,060 enrolled participants provided a complete set of data. Of those randomly assigned to the study arm and tested by FIT, 92 (8.7%) were found to be positive, 39 (11.5%) males and 53 (7.4%) females. The f-Hb concentrations at the 75th, 90th and 95th percentiles for all age groups were higher in males than in females, and the distributions of f-Hb concentration varied with age, especially at the 95th percentile where f-Hb concentrations increased with age. Conclusion: The preliminary results of our screening trial have indicated that the prevalence of positive FIT cases is higher than in a similar recent and, at the time unique, previous study in Thailand. This finding is especially the case for males and those in the older age groups.
原文英語
頁(從 - 到)2883-2889
頁數7
期刊Asian Pacific Journal of Cancer Prevention
18
發行號10
DOIs
出版狀態已發佈 - 十月 1 2017

    指紋

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

引用此

Sarakarn, P., Promthet, S., Vatanasapt, P., Tipsunthonsak, N., Jenwitheesuk, K., Maneenin, N., Jirapornkul, C., Kamsa-Ard, S., Haengsorn, T., Arkkhaboot, C., Chen, S. L. S., Yen, A. M. F., Chiu, S. Y. H., Fann, J. C. Y., & Chen, T. H. H. (2017). Preliminary results: Colorectal cancer screening using fecal immunochemical test (FIT) in a Thai population aged 45-74 years: A population-based randomized controlled trial. Asian Pacific Journal of Cancer Prevention, 18(10), 2883-2889. https://doi.org/10.22034/APJCP.2017.18.10.2883