Preirradiation chemotherapy for very young children with brain tumors

Mei Jy Jeng, Te Kau Chang, Tai-Tong Wong, Yuh Lin Hsien, Ran Bin Tang, Betau Hwang

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

Standard management of malignant brain tumors includes either surgical resection alone or surgery followed by irradiation. However, neuroaxis irradiation administered to very young children for primary intracranial tumors is often associated with major late side effects. To delay irradiation and evaluate the efficacy of preirradiation chemotherapy, we treated 9 young children (aged less than 3 years), who had newly diagnosed brain tumors and underwent total or subtotal resection, with a combination of chemotherapy including vinblastine, cisplatin, and etoposide every 3-4 weeks for 6-14 courses between 1988 and 1992. There were malignat gliomas in four patients, medulloblastomas in three, and ependymomas in two. A response to preirradiation chemotherapy (complete remission or partial remission) occurred in seven out of nine cases. Only one patient had progressive disease during the chemotherapy period. Preirradiation chemotherapy with vinblastine, cisplatin, and etoposide might be a highly effective combination allowing delay of radiation therapy in very young children with brain tumors. Acute and subacute toxicity of chemotherapy in this study was mild.

原文英語
頁(從 - 到)150-153
頁數4
期刊Child's Nervous System
9
發行號3
DOIs
出版狀態已發佈 - 六月 1 1993
對外發佈

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康
  • 神經病學(臨床)

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