Predictive value of serum uric acid levels for the diagnosis of metabolic syndrome in adolescents

Jen Yu Wang, Yen Lin Chen, Chun Hsien Hsu, Sai Hung Tang, Chung Ze Wu, Dee Pei

研究成果: 雜誌貢獻文章同行評審

45 引文 斯高帕斯(Scopus)

摘要

Objective: To evaluate the cause-effect relationships between serum levels of uric acid (UA) and metabolic syndrome (MetS) in an adolescent-male cohort that was followed for 2.7 years. Study design: We enrolled male adolescents aged between 10 and 15 years at the baseline. A total of 613 subjects were divided into quartiles according to their UA levels, from UA-1 (the lowest) to UA-4 (the highest). Results: After the mean follow-up period of 2.7 ± 0.97 years, 19 (3.1%) subjects developed MetS. Waist circumference (WC), systolic blood pressure, high density lipoprotein cholesterol (HDL-C), and log triglyceride levels were significantly related to baseline UA levels. Compared with the UA-1 group, subjects in the UA-4 group had significantly higher OR for abnormal WC, blood pressure, and HDL-C at the end of follow-up and had a 6.39-fold higher OR (95% CI 1.41-29.08; P 7.6 mg/dL had a 4.32 (95% CI 1.57-11.93) higher risk of developing MetS. Conclusions: In this longitudinal study, we found that serum UA is correlated with future WC, systolic blood pressure, triglyceride, and HDL-C and is a risk factor for developing MetS. UA might be valuable in predicting adolescent MetS.

原文英語
期刊Journal of Pediatrics
161
發行號4
DOIs
出版狀態已發佈 - 10月 2012

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康

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