Prediction of proinflammatory potentials of engine exhausts by integrating chemical and biological features

Chia Chi Wang, Ying Chi Lin, Yuan Chung Lin, Syu Ruei Jhang, Chun Wei Tung

研究成果: 書貢獻/報告類型會議貢獻

1 引文 斯高帕斯(Scopus)

摘要

The increasing prevalence of immune-related diseases has raised concerns about immunotoxicity of engine exhausts. The evaluation of immunotoxicity associated with engine exhausts has relied on expensive and timeconsuming experiments. In this study, a computational method named CBM was developed for predicting proinflammatory potentials of engine exhausts using chemical and biological data which are routinely analyzed for toxicity evaluation. The CBM model, based on a principal component regression algorithm, performs well with high correlation coefficient values of 0.972 and 0.849 obtained from training and independent test sets, respectively. In contrast, chemical or biological features alone showed poor correlation with the toxicity. The model indicates the importance of the utilization of both chemical and biological features for developing an effective model. The proposed method could be further developed and applied to predict bioactivities of mixtures.

原文英語
主出版物標題Bioinformatics and Biomedical Engineering - 4th International Conference, IWBBIO 2016, Proceedings
編輯Francisco Ortuno, Ignacio Rojas
發行者Springer Verlag
頁面293-303
頁數11
ISBN(列印)9783319317434
DOIs
出版狀態已發佈 - 一月 1 2016
對外發佈
事件4th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2016 - Granada, 西班牙
持續時間: 四月 20 2016四月 22 2016

出版系列

名字Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
9656
ISSN(列印)0302-9743
ISSN(電子)1611-3349

會議

會議4th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2016
國家/地區西班牙
城市Granada
期間4/20/164/22/16

ASJC Scopus subject areas

  • 理論電腦科學
  • 電腦科學(全部)

指紋

深入研究「Prediction of proinflammatory potentials of engine exhausts by integrating chemical and biological features」主題。共同形成了獨特的指紋。

引用此