摘要
The alpha-2 adrenoceptor radioligand tritiated yohimbine was used to determine the location of pre- versus postsynaptic alpha-2 adrenoceptors in canine nasal mucosa. Using Scatchard analysis, the maximal binding capacity (Bmax) and an apparent equilibrium dissociation constant (Kd) of the alpha-2 adrenoceptor were measured in seven normal dogs and in seven dogs subjected to a unilateral superior cervical ganglionectomy. The results showed that most alpha-2 adrenoceptors in the canine nasal mucosa were located at postsynaptic membranes and very few were located at presynaptic membranes. After superior cervical ganglionectomy, there were no significant changes of the affinity (Kd) and number (Bmax) of the alpha-2 adrenoceptors in the mucosa. These results suggest that the postsynaptic alpha-2 receptors are located extrasynaptically.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 361-363 |
| 頁數 | 3 |
| 期刊 | European Archives of Oto-Rhino-Laryngology |
| 卷 | 247 |
| 發行號 | 6 |
| DOIs | |
| 出版狀態 | 已發佈 - 九月 1990 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Otorhinolaryngology
引用此文
Pre- and post-synaptic alpha-2 adrenoceptors in the canine nasal mucosa. / Wang, H. W.
於: European Archives of Oto-Rhino-Laryngology, 卷 247, 編號 6, 09.1990, p. 361-363.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Pre- and post-synaptic alpha-2 adrenoceptors in the canine nasal mucosa
AU - Wang, H. W.
PY - 1990/9
Y1 - 1990/9
N2 - The alpha-2 adrenoceptor radioligand tritiated yohimbine was used to determine the location of pre- versus postsynaptic alpha-2 adrenoceptors in canine nasal mucosa. Using Scatchard analysis, the maximal binding capacity (Bmax) and an apparent equilibrium dissociation constant (Kd) of the alpha-2 adrenoceptor were measured in seven normal dogs and in seven dogs subjected to a unilateral superior cervical ganglionectomy. The results showed that most alpha-2 adrenoceptors in the canine nasal mucosa were located at postsynaptic membranes and very few were located at presynaptic membranes. After superior cervical ganglionectomy, there were no significant changes of the affinity (Kd) and number (Bmax) of the alpha-2 adrenoceptors in the mucosa. These results suggest that the postsynaptic alpha-2 receptors are located extrasynaptically.
AB - The alpha-2 adrenoceptor radioligand tritiated yohimbine was used to determine the location of pre- versus postsynaptic alpha-2 adrenoceptors in canine nasal mucosa. Using Scatchard analysis, the maximal binding capacity (Bmax) and an apparent equilibrium dissociation constant (Kd) of the alpha-2 adrenoceptor were measured in seven normal dogs and in seven dogs subjected to a unilateral superior cervical ganglionectomy. The results showed that most alpha-2 adrenoceptors in the canine nasal mucosa were located at postsynaptic membranes and very few were located at presynaptic membranes. After superior cervical ganglionectomy, there were no significant changes of the affinity (Kd) and number (Bmax) of the alpha-2 adrenoceptors in the mucosa. These results suggest that the postsynaptic alpha-2 receptors are located extrasynaptically.
KW - Alpha-2 adrenoceptors
KW - Nasal mucosa
UR - http://www.scopus.com/inward/record.url?scp=0025111302&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025111302&partnerID=8YFLogxK
U2 - 10.1007/BF00179007
DO - 10.1007/BF00179007
M3 - Article
C2 - 2177608
AN - SCOPUS:0025111302
VL - 247
SP - 361
EP - 363
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
SN - 0937-4477
IS - 6
ER -