Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous infusion

Peter P.C. Tan, Ming Hwang Shyr, Chen Hsein Yang, Terry B.J. Kuo, Wynn H.T. Pan, Samuel H.H. Chan

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that effective antinociception could be achieved in adult male Sprague-Dawley rats 15 min after intravenous infusion of propofol at 60 mg/kg/h. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant depression of the activity of all EEG frequency bands (δ, θ, α, β), alongside hypotension, negative inotropic and chronotropic actions, and attenuated baroreceptor reflex and vasomotor activity. These effects were congruent with a plasma concentration of propofol in the arterial blood of 1.70 ± 0.13 μg/ml, as determined by high-performance liquid chromatography.
原文英語
頁(從 - 到)205-208
頁數4
期刊Neuroscience Letters
160
發行號2
DOIs
出版狀態已發佈 - 十月 1 1993
對外發佈Yes

ASJC Scopus subject areas

  • Neuroscience(all)

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