Power spectral analysis of electromyographic and systemic arterial pressure signals during fentanyl-induced muscular rigidity in the rat

T. Y. Lee, M. J. Fu, T. B.J. Kuo, P. W. Lui, S. H.H. Chan

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14 引文 斯高帕斯(Scopus)

摘要

We have measured electromyographic (EMG) and systemic arterial pressure (SAP) signals during fentanyi-induced muscular rigidity in adult male Sprague-Dawley rats anaesthetized initially with ketamine 120 mg kg-1 i.p. during controlled ventilation. Fentanyl 100 μg kg-1 i.v. induced significant increase in EMG activity, recorded from the sacrococcygeus dorsi lateralis muscle. Power spectral analysis revealed that this was produced by an increase in the root mean square and a decrease in the mean power frequency values of the signals, signifying recruitment and synchronous activation of motor units. Together with transient hypotension and bradycardia, power spectral analysis of the SA P signals demonstrated a reduced but maintained power density of the frequency components that represent respiratory, baroreceptor and vasomotor activities. All these effects were only demonstrated unequivocally in rats maintained by i.v. infusion of ketamine until 10 min before the administration of fentanyl. We conclude that analysis of the temporal alterations in the spectral components of the EMG and SAP signals in rats during mechanical ventilation provides a sensitive method of measuring fentanyi-induced muscular rigidity and the accompanying alterations in haemodynamic variables. (Br. J. Anaesth. 1994; 72: 328-334)
原文英語
頁(從 - 到)328-334
頁數7
期刊British Journal of Anaesthesia
72
發行號3
DOIs
出版狀態已發佈 - 3月 1994
對外發佈

ASJC Scopus subject areas

  • 麻醉與疼痛醫學

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