Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex

Chu Jen Kuo, Chi Chen Huang, Szu Yi Chou, Yu Chun Lo, Tzu Jen Kao, Nai Kuei Huang, Connie Lin, Hsin Chuan Lin, Hui Ching Lin, Yi Chao Lee

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Background: Curcumin is a polyphenol natural product of the plant Curcuma longa. Recent studies suggest that curcumin inhibit mTOR activity in vitro, which prompts us to investigate curcumin function as a new class of mTOR inhibitor suitable for tuberous sclerosis complex (TSC) treatment. Purpose: We aim to investigate the efficacy of curcumin in the treatment of TSC related manifestations in animal model. Study Design: Solid lipid curcumin particle (SLCP), a novel curcumin formulation, was used to treat TSC related manifestations in Tsc2 knockout mice. Methods: The novel object recognition test was used to analyze the recognition memory function. The long-term potentiation was studied using electrophysiological analysis. Western blotting was used to assess the protein expression and activation status. Results: Recognition memory deficit began as early as 4 weeks of age in both male and female Tsc2+/− mice. Oral administration with SLCP activates AMPK activity and inhibits mTOR activity in the brain tissue of Tsc2+/− mice, and can rescue the electrophysiological abnormality and object recognition memory loss in the mice. Conclusions: Our results suggest that SLCP could be an effective treatment for TSC patients.
原文英語
頁(從 - 到)132-139
頁數8
期刊Phytomedicine
54
DOIs
出版狀態已發佈 - 二月 15 2019

Keywords

  • Curcumin
  • Solid lipid curcumin particle
  • Tuberous sclerosis complex

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

指紋 深入研究「Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex」主題。共同形成了獨特的指紋。

  • 引用此