Potential of an age-stratified CA125 cut-off value to improve the prognostic classification of patients with endometrial cancer

Angel Chao, Yun Hsin Tang, Chyong Huey Lai, Chee Jen Chang, Shu Chen Chang, Tzu I. Wu, Swei Hsueh, Chin Jung Wang, Hung Hsueh Chou, Ting Chang Chang

研究成果: 雜誌貢獻文章同行評審

28 引文 斯高帕斯(Scopus)

摘要

Objective It is not clear whether the prognostic value of pretreatment serum CA125 levels is independent or through association with other clinicopathological features in endometrial cancer. Methods All patients with endometrial cancer treated between 2000 and 2010 were retrospectively reviewed. The correlation of clinicopathological characteristics, CA125 and treatment outcomes was analyzed. Receiver operating characteristics (ROC) curves were used to determine the CA125 cut-off values. Cox proportional hazard regression was used for multivariate analysis. Results Of the 923 eligible patients, 757 had serum CA125 levels measured before treatment. We identified 264 (34.9%) patients with pretreatment serum CA125 > 35 U/mL. By multivariate analysis, advanced stage (P = 0.001), serous or clear cell carcinoma (P = 0.008), positive peritoneal cytology (P = 0.042), and lymph node metastases (P = 0.004) were significant risk factors for cancer-specific survival (CSS), while serum CA125 > 35 U/mL (P = 0.067) was of borderline statistical significance. Using ROC curve stratified by age, we found that a serum CA125 > 35 U/mL was significant for CSS (HR = 2.34, 95% CI = 1.04-5.29) among patients > 49 years old. After adjustment for confounding factors, serum CA125 > 105 U/mL was significant (HR = 6.03, 95% CI = 1.19-30.63) in patients ≤ 49 years old. Conclusions These results suggest that an age-stratified cut-off level for CA125 (35 U/mL in patients > 49 years old and 105 U/mL in patients ≤ 49 years old) can improve the prognostic stratification of patients with endometrial cancer.

原文英語
頁(從 - 到)500-504
頁數5
期刊Gynecologic Oncology
129
發行號3
DOIs
出版狀態已發佈 - 6月 2013

ASJC Scopus subject areas

  • 腫瘤科
  • 婦產科

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