Potential mechanism of blood vessel protection by resveratrol, a component of red wine

Huei Mei Huang, Yu Chih Liang, Tzu-Hurng Cheng, Cheng Heien Chen, Shu Hui Juan

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)

摘要

Resveratrol-mediated heme oxgenase-1 (HO-1) induction has been shown to occur in primary neuronal cultures and has been implicated as having potential neuroprotective action. Further, antioxidant properties of resveratrol have been reported to protect against coronary heart disease. We attempted to examine the HO-1 inducing potency of resveratrol and the regulatory mechanism of its induction in rat aortic smooth muscle cells (RASMC). We showed that resveratrol-induced HO-1 expression was concentration- and time-dependent. The level of HO-1 expression and its promoter activity mediated by resveratrol was attenuated by nuclear factor-kappa B (NF-κB) inhibitors, but not by mitogen-activated protein kinase (MAPK) inhibitors. Deletion of NF-κB binding sites in the promoter region strongly reduced luciferase activity. Collectively, we suggest that resveratrol-mediated HO-1 expression occurs, at least in part, through the NF-κB pathway.
原文英語
頁(從 - 到)349-356
頁數8
期刊Annals of the New York Academy of Sciences
1042
DOIs
出版狀態已發佈 - 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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