Potential involvement of IL-17F in asthma

Kyoko Ota, Mio Kawaguchi, Satoshi Matsukura, Masatsugu Kurokawa, Fumio Kokubu, Junichi Fujita, Yuko Morishima, Shau Ku Huang, Yukio Ishii, Hiroaki Satoh, Nobuyuki Hizawa

研究成果: 雜誌貢獻回顧型文獻

28 引文 斯高帕斯(Scopus)

摘要

The expression of IL-17F is seen in the airway of asthmatics and its level is correlated with disease severity. Several studies have demonstrated that IL-17F plays a pivotal role in allergic airway inflammation and induces several asthma-related molecules such as CCL20. IL-17F-induced CCL20 may attract Th17 cells into the airway resulting in the recruitment of additional Th17 cells to enhance allergic airway inflammation. We have recently identified, for the first time, that bronchial epithelial cells are its novel cell source in response to IL-33 via ST2-ERK1/2-MSK1 signaling pathway. The receptor for IL-17F is the heterodimeric complex of IL-17RA and IL-17RC, and IL-17F activates many signaling pathways. In a case-control study of 867 unrelated Japanese subjects, a His161 to Arg161 (H161R) substitution in the third exon of the IL-17F gene was associated with asthma. In atopic patients with asthma, prebronchodilator baseline FEV1/FVC values showed a significant association with the H161R variant. Moreover, this variant is a natural antagonist for the wild-type IL-17F. Moreover, IL-17F is involved in airway remodeling and steroid resistance. Hence, IL-17F may play an orchestrating role in the pathogenesis of asthma and may provide a valuable therapeutic target for development of novel strategies.

原文英語
文章編號602846
期刊Journal of Immunology Research
2014
DOIs
出版狀態已發佈 - 一月 1 2014
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

引用此

Ota, K., Kawaguchi, M., Matsukura, S., Kurokawa, M., Kokubu, F., Fujita, J., Morishima, Y., Huang, S. K., Ishii, Y., Satoh, H., & Hizawa, N. (2014). Potential involvement of IL-17F in asthma. Journal of Immunology Research, 2014, [602846]. https://doi.org/10.1155/2014/602846