Potential drug interactions in dermatologic outpatient prescriptions - Experience from nationwide population-based study in Taiwan

Ying Jui Chang, Min Li Yeh, Yu Chuan Li, Chien-Yeh Hsu, Yung Tai Yen, Po Yen Wang, Thomas Waitao Chu

研究成果: 雜誌貢獻文章

8 引文 (Scopus)

摘要

Background: Adverse drug reactions increase morbidity and mortality, and potential drug interactions (DIs) increase the probability of adverse drug reactions. Objectives: To survey the potential DIs of dermatologic outpatient prescriptions from the National Health Insurance Research Database of Taiwan. Methods: All prescriptions written by dermatologists in 2000 were analyzed to identify potential DIs among drugs appearing on the same prescription sheet. Results: Of 150.6 million prescription sheets with 669.5 million prescriptions registered in the National Health Insurance Research Database of Taiwan, we identified 6.6 million (4.4%) dermatology prescription sheets with 19 million (2.8%) prescriptions. The findings of the study showed that 283,458 potential DIs were found in this category, accounting for 1.49% per prescription. The most common significance Level 1 interaction (1.1%) was between the less-sedative antihistamines (terfenadine/astemizole) and azole antifungal agents. Among the category of severity, the most common was terfenadine interacting with cimetidine and ketoconazole (4.4%), followed by astemizole interacting with cimetidine and ketoconazole (2.9%). The most common drug class interaction occurred between corticosteroids and antacids (48.5%). Overall, DI incidence in dermatologic patients was lower than that of the general patient population. Conclusions: Based on the study findings, we concluded that dermatologists need to be reminded of having possible potential DIs when prescribing medications. Introducing information technology into the computerized physician order entry system into the daily practice may reduce potential DIs.

原文英語
頁(從 - 到)81-85
頁數5
期刊Dermatologica Sinica
29
發行號3
DOIs
出版狀態已發佈 - 九月 2011

指紋

Taiwan
Drug Interactions
Prescriptions
Outpatients
Population
Astemizole
Terfenadine
Ketoconazole
Cimetidine
National Health Programs
Drug-Related Side Effects and Adverse Reactions
Medical Order Entry Systems
Databases
Azoles
Antacids
Antifungal Agents
Histamine Antagonists
Dermatology
Hypnotics and Sedatives
Research

ASJC Scopus subject areas

  • Dermatology

引用此文

Potential drug interactions in dermatologic outpatient prescriptions - Experience from nationwide population-based study in Taiwan. / Chang, Ying Jui; Yeh, Min Li; Li, Yu Chuan; Hsu, Chien-Yeh; Yen, Yung Tai; Wang, Po Yen; Chu, Thomas Waitao.

於: Dermatologica Sinica, 卷 29, 編號 3, 09.2011, p. 81-85.

研究成果: 雜誌貢獻文章

Chang, Ying Jui ; Yeh, Min Li ; Li, Yu Chuan ; Hsu, Chien-Yeh ; Yen, Yung Tai ; Wang, Po Yen ; Chu, Thomas Waitao. / Potential drug interactions in dermatologic outpatient prescriptions - Experience from nationwide population-based study in Taiwan. 於: Dermatologica Sinica. 2011 ; 卷 29, 編號 3. 頁 81-85.
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abstract = "Background: Adverse drug reactions increase morbidity and mortality, and potential drug interactions (DIs) increase the probability of adverse drug reactions. Objectives: To survey the potential DIs of dermatologic outpatient prescriptions from the National Health Insurance Research Database of Taiwan. Methods: All prescriptions written by dermatologists in 2000 were analyzed to identify potential DIs among drugs appearing on the same prescription sheet. Results: Of 150.6 million prescription sheets with 669.5 million prescriptions registered in the National Health Insurance Research Database of Taiwan, we identified 6.6 million (4.4{\%}) dermatology prescription sheets with 19 million (2.8{\%}) prescriptions. The findings of the study showed that 283,458 potential DIs were found in this category, accounting for 1.49{\%} per prescription. The most common significance Level 1 interaction (1.1{\%}) was between the less-sedative antihistamines (terfenadine/astemizole) and azole antifungal agents. Among the category of severity, the most common was terfenadine interacting with cimetidine and ketoconazole (4.4{\%}), followed by astemizole interacting with cimetidine and ketoconazole (2.9{\%}). The most common drug class interaction occurred between corticosteroids and antacids (48.5{\%}). Overall, DI incidence in dermatologic patients was lower than that of the general patient population. Conclusions: Based on the study findings, we concluded that dermatologists need to be reminded of having possible potential DIs when prescribing medications. Introducing information technology into the computerized physician order entry system into the daily practice may reduce potential DIs.",
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