摘要

Sensitive and reliable early diagnostic markers for oral squamous cell carcinoma (OSCC) remain unavailable. Early identification of recurrence for OSCC is also a challenge. Unlike the other deep cancers, OSCC is located in oral cavity. The DNA, RNA, and protein derived from the living cancer cells and inflammatory cells then can be conveniently obtained from saliva. High-throughput genomic and proteomic approaches have been carried out to identify the potential biomarkers in body fluids such as saliva and blood for diagnosis and prognosis of OSCC. This article reviewed the recently identified biomarkers from saliva for OSCC. In addition, the biomarkers which have been correlated with OSCC tumor malignancy by molecular pathology analysis are also described. Finally, the potential biomarkers that have been demonstrated to associate with the malignant OSCC may be used for salivary screening for high-risk patients are suggested. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis for high-risk patients of OSCC. Effective screening to identify high-risk patients can allow the clinician to provide the appropriate treatment without delay and to reduce the recurrence of OSCC.
原文英語
頁(從 - 到)226-231
頁數6
期刊Oral Oncology
46
發行號4
DOIs
出版狀態已發佈 - 四月 2010

指紋

Saliva
Squamous Cell Carcinoma
Biomarkers
Molecular Pathology
Recurrence
Oral Diagnosis
Neoplasms
Mouth Neoplasms
Body Fluids
Proteomics
Mouth
RNA
DNA

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research

引用此文

Potential biomarkers in saliva for oral squamous cell carcinoma. / Wu, Jia Yo; Yi, Chen; Chung, Ho Ren; Wang, Duen Jeng; Chang, Wen Chien; Lee, Sheng Yang; Lin, Che Tung; Yang, Yueh Chao; Yang, Wei Chung Vivian.

於: Oral Oncology, 卷 46, 編號 4, 04.2010, p. 226-231.

研究成果: 雜誌貢獻回顧型文獻

Wu, JY, Yi, C, Chung, HR, Wang, DJ, Chang, WC, Lee, SY, Lin, CT, Yang, YC & Yang, WCV 2010, 'Potential biomarkers in saliva for oral squamous cell carcinoma', Oral Oncology, 卷 46, 編號 4, 頁 226-231. https://doi.org/10.1016/j.oraloncology.2010.01.007
Wu, Jia Yo ; Yi, Chen ; Chung, Ho Ren ; Wang, Duen Jeng ; Chang, Wen Chien ; Lee, Sheng Yang ; Lin, Che Tung ; Yang, Yueh Chao ; Yang, Wei Chung Vivian. / Potential biomarkers in saliva for oral squamous cell carcinoma. 於: Oral Oncology. 2010 ; 卷 46, 編號 4. 頁 226-231.
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abstract = "Sensitive and reliable early diagnostic markers for oral squamous cell carcinoma (OSCC) remain unavailable. Early identification of recurrence for OSCC is also a challenge. Unlike the other deep cancers, OSCC is located in oral cavity. The DNA, RNA, and protein derived from the living cancer cells and inflammatory cells then can be conveniently obtained from saliva. High-throughput genomic and proteomic approaches have been carried out to identify the potential biomarkers in body fluids such as saliva and blood for diagnosis and prognosis of OSCC. This article reviewed the recently identified biomarkers from saliva for OSCC. In addition, the biomarkers which have been correlated with OSCC tumor malignancy by molecular pathology analysis are also described. Finally, the potential biomarkers that have been demonstrated to associate with the malignant OSCC may be used for salivary screening for high-risk patients are suggested. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis for high-risk patients of OSCC. Effective screening to identify high-risk patients can allow the clinician to provide the appropriate treatment without delay and to reduce the recurrence of OSCC.",
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AU - Wu, Jia Yo

AU - Yi, Chen

AU - Chung, Ho Ren

AU - Wang, Duen Jeng

AU - Chang, Wen Chien

AU - Lee, Sheng Yang

AU - Lin, Che Tung

AU - Yang, Yueh Chao

AU - Yang, Wei Chung Vivian

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N2 - Sensitive and reliable early diagnostic markers for oral squamous cell carcinoma (OSCC) remain unavailable. Early identification of recurrence for OSCC is also a challenge. Unlike the other deep cancers, OSCC is located in oral cavity. The DNA, RNA, and protein derived from the living cancer cells and inflammatory cells then can be conveniently obtained from saliva. High-throughput genomic and proteomic approaches have been carried out to identify the potential biomarkers in body fluids such as saliva and blood for diagnosis and prognosis of OSCC. This article reviewed the recently identified biomarkers from saliva for OSCC. In addition, the biomarkers which have been correlated with OSCC tumor malignancy by molecular pathology analysis are also described. Finally, the potential biomarkers that have been demonstrated to associate with the malignant OSCC may be used for salivary screening for high-risk patients are suggested. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis for high-risk patients of OSCC. Effective screening to identify high-risk patients can allow the clinician to provide the appropriate treatment without delay and to reduce the recurrence of OSCC.

AB - Sensitive and reliable early diagnostic markers for oral squamous cell carcinoma (OSCC) remain unavailable. Early identification of recurrence for OSCC is also a challenge. Unlike the other deep cancers, OSCC is located in oral cavity. The DNA, RNA, and protein derived from the living cancer cells and inflammatory cells then can be conveniently obtained from saliva. High-throughput genomic and proteomic approaches have been carried out to identify the potential biomarkers in body fluids such as saliva and blood for diagnosis and prognosis of OSCC. This article reviewed the recently identified biomarkers from saliva for OSCC. In addition, the biomarkers which have been correlated with OSCC tumor malignancy by molecular pathology analysis are also described. Finally, the potential biomarkers that have been demonstrated to associate with the malignant OSCC may be used for salivary screening for high-risk patients are suggested. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis for high-risk patients of OSCC. Effective screening to identify high-risk patients can allow the clinician to provide the appropriate treatment without delay and to reduce the recurrence of OSCC.

KW - Biomarker

KW - Body fluid

KW - Diagnosis

KW - Genomics

KW - Oral squamous cell carcinoma

KW - Prognosis

KW - Proteomics

KW - Saliva

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