Postnatal corticosteroids for prevention and treatment of chronic lung disease in the preterm newborn

Sachin Gupta, Kaninghat Prasanth, Chung-Ming Chen, Tsu F Yeh

研究成果: 雜誌貢獻文章同行評審

摘要

Despite significant progress in the treatment of preterm neonates, bronchopulmonary dysplasia (BPD) continues to be a major cause of neonatal morbidity. Affected infants suffered from long-term pulmonary and nonpulmonary sequel. The pulmonary sequels include reactive airway disease and asthma during childhood and adolescence. Nonpulmonary sequels include poor coordination and muscle tone, difficulty in walking, vision and hearing problems, delayed cognitive development, and poor academic achievement. As inflammation seems to be a primary mediator of injury in pathogenesis of BPD, role of steroids as antiinflammatory agent has been extensively studied and proven to be efficacious in management. However, evidence is insufficient to make a recommendation regarding other glucocorticoid doses and preparations. Numerous studies have been performed to investigate the effects of steroid. The purpose of this paper is to evaluate these studies in order to elucidate the beneficial and harmful effects of steroid on the prevention and treatment of BPD.
原文英語
頁(從 - 到)315642
期刊Anales de Pediatria
2012
DOIs
出版狀態已發佈 - 2012

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