TY - JOUR
T1 - Post-traumatic Cerebrospinal Fluid Leakage
T2 - A Risk Indicator to Predict Outcome Following Traumatic Brain Injury?
AU - Chiu, Wen Ta
AU - Tsai, Shin Han
AU - Tsai, Wan Chen
AU - Lin, Jia Wei
AU - Hung, Kuo Sheng
AU - Lin, Tien Jen
PY - 2010/2
Y1 - 2010/2
N2 - Background/Purpose: The aim of the present study was to review the clinical manifestations, risk factors and outcome in traumatic brain injury (TBI) patients with post-traumatic cerebrospinal fluid (CSF) leakage. Methods: We reviewed the medical records of 1,323 patients who were identified with CSF leakage that occurred after head trauma. Results: Patients complicated with CSF leakage manifested a more rigorous clinical course and poorer outcome compared to patients with other TBI features: in mild head injury, patients with brain injury complicated with CSF leakage alone had a 24.5% risk ratio for developing intracranial hemorrhage, and the presence of post-traumatic CSF leakage with or without skull fracture resulted in a higher percentage of fatality. Conclusion: Post-traumatic CSF leakage amongst head injury patients has serious complications in nonfatal TBI cases, and indicates a risk of developing post-traumatic intracranial hemorrhage as the patients' final outcome.
AB - Background/Purpose: The aim of the present study was to review the clinical manifestations, risk factors and outcome in traumatic brain injury (TBI) patients with post-traumatic cerebrospinal fluid (CSF) leakage. Methods: We reviewed the medical records of 1,323 patients who were identified with CSF leakage that occurred after head trauma. Results: Patients complicated with CSF leakage manifested a more rigorous clinical course and poorer outcome compared to patients with other TBI features: in mild head injury, patients with brain injury complicated with CSF leakage alone had a 24.5% risk ratio for developing intracranial hemorrhage, and the presence of post-traumatic CSF leakage with or without skull fracture resulted in a higher percentage of fatality. Conclusion: Post-traumatic CSF leakage amongst head injury patients has serious complications in nonfatal TBI cases, and indicates a risk of developing post-traumatic intracranial hemorrhage as the patients' final outcome.
KW - cerebrospinal fluid leakage
KW - intracranial hemorrhage
KW - post-traumatic amnesia
KW - skull fracture
KW - traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=77949306262&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949306262&partnerID=8YFLogxK
U2 - 10.1016/S1878-3317(10)60005-8
DO - 10.1016/S1878-3317(10)60005-8
M3 - Article
AN - SCOPUS:77949306262
SN - 1878-3317
VL - 2
SP - 29
EP - 34
JO - Journal of Experimental and Clinical Medicine
JF - Journal of Experimental and Clinical Medicine
IS - 1
ER -