Post-insult valproate treatment potentially improved functional recovery in patients with acute middle cerebral artery infarction

Jiunn Tay Lee, Chung Hsing Chou, Nai Yu Cho, Yueh Feng Sung, Fu Chi Yang, Cheng Yu Chen, Yu Hua Lai, Chun I. Chiang, Chi Ming Chu, Jiann Chyun Lin, Yaw Don Hsu, Jau Shyong Hong, Giia Sheun Peng, De Maw Chuang

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5 引文 斯高帕斯(Scopus)

摘要

Animal stroke models suggest that valproate has multiple neuroprotective mechanisms against ischemic brain damage. This study investigated whether valproate improves functional recovery in patients with acute middle cerebral artery (MCA) infarction. This was an open-label controlled trial. Three to 24 hours after acute MCA infarction, patients were assigned to either the valproate group (n = 17) or the non-valproate group (n = 17). The valproate group received intravenous valproate (400 mg) at enrollment, and then every 12 hours for three days, followed by oral valproate (500 mg) every 12 hours for three months. Neurological function, laboratory data, and brain magnetic resonance imaging were examined at stroke onset, and at two-week and three-month follow-up. No signifcant differences were observed between the groups with regard to demographics or baseline characteristics. All patients were elderly, had a high pretreatment score on the NIH stroke scale (NIHSS), and slow stroke lesion growth with a fnal large infarct volume at two-week follow-up. At the three-month follow-up, functional outcome between pre- and post-treatment had improved signifcantly in the valproate group (NIHSS, p = 0.004; modifed Rankin scale (mRS), p = 0.007; Barthel index (BI), p = 0.001). No such improvement was noted in the NIHSS or mRS for the non-valproate group, though mild improvement was seen on the BI (p = 0.022). This open-label trial is the frst to demonstrate that valproate treatment markedly improves functional outcome in patients with acute MCA infarction.
原文英語
頁(從 - 到)820-830
頁數11
期刊American Journal of Translational Research
6
發行號6
出版狀態已發佈 - 2014

ASJC Scopus subject areas

  • 醫藥 (全部)
  • 癌症研究
  • 臨床生物化學
  • 分子醫學

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