Possible effects of anaesthetic management on the 1 yr followed-up risk of herpes zoster after Caesarean deliveries

Y. H. Chen, R. H. Rau, J. J. Keller, H. C. Lin

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

BackgroundAs general anaesthesia may compromise the immune system, it has been hypothesized that latent varicella-zoster virus is more likely to be reactivated and cause herpes zoster in mothers after Caesarean deliveries under general anaesthesia. Our study was thus aimed at investigating the risk of herpes zoster among women during the first year after Caesarean deliveries under either general or regional anaesthesia. MethodsTwo nationwide population-based data sets were utilized, including the Taiwan birth certificate registry and the Taiwan National Health Insurance Research Dataset. From 2001 to 2003, a total of 162 495 women underwent Caesarean delivery. Among them, 21 454 women received general anaesthesia, whereas 141 041 patients received regional anaesthesia. Each individual was followed for 1 yr to identify the subsequent occurrence of herpes zoster. Coxs proportional hazards regressions were performed for analysis. ResultsDuring the 1 yr follow-up period, 0.46 of the women receiving general anaesthesia experienced an episode of herpes zoster, compared with 0.34 of women receiving regional anaesthesia. In Caesarean deliveries, the use of general anaesthesia compared with regional anaesthesia was independently associated with a 1.29-fold (95 confidence interval1.041.61) increase in the 1 yr risk of herpes zoster, after adjusting for maternal and infant characteristics. ConclusionsIn this series, there was a small increased risk of herpes zoster in the year after Caesarean delivery with general anaesthesia. Future studies are needed to further investigate these findings.
原文英語
頁(從 - 到)278-282
頁數5
期刊British Journal of Anaesthesia
108
發行號2
DOIs
出版狀態已發佈 - 二月 2012

指紋

Herpes Zoster
General Anesthesia
Anesthetics
Conduction Anesthesia
Taiwan
Mothers
Birth Certificates
Human Herpesvirus 3
National Health Programs
Registries
Immune System
Research
Population

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

引用此文

Possible effects of anaesthetic management on the 1 yr followed-up risk of herpes zoster after Caesarean deliveries. / Chen, Y. H.; Rau, R. H.; Keller, J. J.; Lin, H. C.

於: British Journal of Anaesthesia, 卷 108, 編號 2, 02.2012, p. 278-282.

研究成果: 雜誌貢獻文章

@article{0b806659290e46059ca3d283f461c925,
title = "Possible effects of anaesthetic management on the 1 yr followed-up risk of herpes zoster after Caesarean deliveries",
abstract = "BackgroundAs general anaesthesia may compromise the immune system, it has been hypothesized that latent varicella-zoster virus is more likely to be reactivated and cause herpes zoster in mothers after Caesarean deliveries under general anaesthesia. Our study was thus aimed at investigating the risk of herpes zoster among women during the first year after Caesarean deliveries under either general or regional anaesthesia. MethodsTwo nationwide population-based data sets were utilized, including the Taiwan birth certificate registry and the Taiwan National Health Insurance Research Dataset. From 2001 to 2003, a total of 162 495 women underwent Caesarean delivery. Among them, 21 454 women received general anaesthesia, whereas 141 041 patients received regional anaesthesia. Each individual was followed for 1 yr to identify the subsequent occurrence of herpes zoster. Coxs proportional hazards regressions were performed for analysis. ResultsDuring the 1 yr follow-up period, 0.46 of the women receiving general anaesthesia experienced an episode of herpes zoster, compared with 0.34 of women receiving regional anaesthesia. In Caesarean deliveries, the use of general anaesthesia compared with regional anaesthesia was independently associated with a 1.29-fold (95 confidence interval1.041.61) increase in the 1 yr risk of herpes zoster, after adjusting for maternal and infant characteristics. ConclusionsIn this series, there was a small increased risk of herpes zoster in the year after Caesarean delivery with general anaesthesia. Future studies are needed to further investigate these findings.",
keywords = "anaesthesia, general, anaesthesia, regional, Caesarean section, herpes zoster, immunity",
author = "Chen, {Y. H.} and Rau, {R. H.} and Keller, {J. J.} and Lin, {H. C.}",
year = "2012",
month = "2",
doi = "10.1093/bja/aer386",
language = "English",
volume = "108",
pages = "278--282",
journal = "British Journal of Anaesthesia",
issn = "0007-0912",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Possible effects of anaesthetic management on the 1 yr followed-up risk of herpes zoster after Caesarean deliveries

AU - Chen, Y. H.

AU - Rau, R. H.

AU - Keller, J. J.

AU - Lin, H. C.

PY - 2012/2

Y1 - 2012/2

N2 - BackgroundAs general anaesthesia may compromise the immune system, it has been hypothesized that latent varicella-zoster virus is more likely to be reactivated and cause herpes zoster in mothers after Caesarean deliveries under general anaesthesia. Our study was thus aimed at investigating the risk of herpes zoster among women during the first year after Caesarean deliveries under either general or regional anaesthesia. MethodsTwo nationwide population-based data sets were utilized, including the Taiwan birth certificate registry and the Taiwan National Health Insurance Research Dataset. From 2001 to 2003, a total of 162 495 women underwent Caesarean delivery. Among them, 21 454 women received general anaesthesia, whereas 141 041 patients received regional anaesthesia. Each individual was followed for 1 yr to identify the subsequent occurrence of herpes zoster. Coxs proportional hazards regressions were performed for analysis. ResultsDuring the 1 yr follow-up period, 0.46 of the women receiving general anaesthesia experienced an episode of herpes zoster, compared with 0.34 of women receiving regional anaesthesia. In Caesarean deliveries, the use of general anaesthesia compared with regional anaesthesia was independently associated with a 1.29-fold (95 confidence interval1.041.61) increase in the 1 yr risk of herpes zoster, after adjusting for maternal and infant characteristics. ConclusionsIn this series, there was a small increased risk of herpes zoster in the year after Caesarean delivery with general anaesthesia. Future studies are needed to further investigate these findings.

AB - BackgroundAs general anaesthesia may compromise the immune system, it has been hypothesized that latent varicella-zoster virus is more likely to be reactivated and cause herpes zoster in mothers after Caesarean deliveries under general anaesthesia. Our study was thus aimed at investigating the risk of herpes zoster among women during the first year after Caesarean deliveries under either general or regional anaesthesia. MethodsTwo nationwide population-based data sets were utilized, including the Taiwan birth certificate registry and the Taiwan National Health Insurance Research Dataset. From 2001 to 2003, a total of 162 495 women underwent Caesarean delivery. Among them, 21 454 women received general anaesthesia, whereas 141 041 patients received regional anaesthesia. Each individual was followed for 1 yr to identify the subsequent occurrence of herpes zoster. Coxs proportional hazards regressions were performed for analysis. ResultsDuring the 1 yr follow-up period, 0.46 of the women receiving general anaesthesia experienced an episode of herpes zoster, compared with 0.34 of women receiving regional anaesthesia. In Caesarean deliveries, the use of general anaesthesia compared with regional anaesthesia was independently associated with a 1.29-fold (95 confidence interval1.041.61) increase in the 1 yr risk of herpes zoster, after adjusting for maternal and infant characteristics. ConclusionsIn this series, there was a small increased risk of herpes zoster in the year after Caesarean delivery with general anaesthesia. Future studies are needed to further investigate these findings.

KW - anaesthesia, general

KW - anaesthesia, regional

KW - Caesarean section

KW - herpes zoster

KW - immunity

UR - http://www.scopus.com/inward/record.url?scp=84863067963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863067963&partnerID=8YFLogxK

U2 - 10.1093/bja/aer386

DO - 10.1093/bja/aer386

M3 - Article

C2 - 22157850

AN - SCOPUS:84863067963

VL - 108

SP - 278

EP - 282

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

SN - 0007-0912

IS - 2

ER -