Positive correlation of serum fibroblast growth factor 23 with peripheral arterial stiffness in kidney transplantation patients

Yao Chang Liu, Jen Pi Tsai, Li Hsuan Wang, Ming Che Lee, Bang Gee Hsu

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Background: Fibroblast growth factor 23 (FGF-23) has a role in arterial stiffness (AS) apart from regulating mineral metabolism. We investigated the association between FGF-23 concentration and peripheral AS in renal transplantation (RT) recipients. Methods: The fasting blood samples of RT recipients (n = 66) were collected and analyzed. Results: A total of 29 (43.9%) RT recipients were classified under the peripheral AS group. The RT recipients in this group had a higher prevalence of diabetes (P < 0.001), hypertension (P = 0.001), and metabolic syndrome (P = 0.023); longer post-RT duration (P = 0.006); higher systolic blood pressure (P < 0.001) and diastolic blood pressure (P = 0.024); and higher fasting glucose (P = 0.002), total cholesterol (P = 0.049), blood urea nitrogen (P = 0.027), phosphorus (P = 0.047), and FGF-23 concentrations (P = 0.003) and FGF-23/α-klotho ratio (P < 0.001) but lower klotho concentrations (P = 0.025) than those in the control group. Moreover, FGF-23 concentration (adjusted odds ratio: 1.057, 95% confidence interval: 1.011–1.105, P = 0.015) was found to be an independent predictor of peripheral AS in RT recipients. Conclusions: Serum FGF-23 concentration was a significant predictor of peripheral AS in RT recipients.

原文英語
頁(從 - 到)9-14
頁數6
期刊Clinica Chimica Acta
505
DOIs
出版狀態已發佈 - 6月 2020
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 臨床生物化學
  • 生物化學(醫學)

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