Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination

Che Ming Hung, Shinn Chih Wu, Chih Ching Yen, Ming Fong Lin, Yi Wen Lai, Yu Tang Tung, Hsiao Ling Chen, Chuan Mu Chen

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

摘要

In this study, recombinant porcine lactoferrin (PLF) was used as feedstuff additive to investigate the effects of peripheral lymphocyte proliferation and serum antibody titers in chickens vaccinated against the infectious bursal disease (IBD) virus. Treatment groups were fed three doses of PLF powder in their diet (0.5, 1.0, and 2.0% w/w), and the IBD vaccine was administrated at 1 and 3 weeks of age. At 8, 12, and 16 weeks after vaccination, serum IBD antibody titers were measured via the micro-method and T cell proliferation rates were evaluated. The results revealed that a high dose of PLF led to significant increases in serum IgA, IgG and IBD-specific antibody titers (P < 0.05). PLF administration, at either low or high doses, enhanced the expression of IFN-γ and IL-12 in chicken T lymphocytes. These results suggest that PLF enhances cell-mediated immunity and augment the ability of IBD vaccination to strengthen subsequent anti-viral responses.
原文英語
頁(從 - 到)579-587
頁數9
期刊BioMetals
23
發行號3
DOIs
出版狀態已發佈 - 六月 2010
對外發佈Yes

ASJC Scopus subject areas

  • Biomaterials
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Metals and Alloys

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    Hung, C. M., Wu, S. C., Yen, C. C., Lin, M. F., Lai, Y. W., Tung, Y. T., Chen, H. L., & Chen, C. M. (2010). Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination. BioMetals, 23(3), 579-587. https://doi.org/10.1007/s10534-010-9321-5