Population-based proband-oriented pedigree information system: Application to hypertension with population-based screening data (KCIS No. 25)

Sherry Yueh Hsia Chiu, Li Sheng Chen, Amy Ming Fang Yen, Hsiu Hsi Chen

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Objective: To develop a population-based probandoriented pedigree information system that can be easily applied to various diseases in genetic epidemiological studies, making allowance for the capture of theoretical family relationships. Designs and Measurements: A population-based proband-oriented pedigree information system with ties of consanguinity based on both population-based household registry data and Keelung Community Integrated Screening data was proposed to build a comprehensive extended family pedigree structure to accommodate a series of genetic studies on different diseases. We also developed an algorithm to efficiently assess how well theoretical family relationships affecting the occurrence of diseases across three generations with respect to the relative relationship score, a quantitative indicator of genetic influence, were captured. Results: We applied this population-based probandoriented pedigree information system to estimate the rate of hypertension with various relative relationships given the selection of probands. The degree of capturing complete familial relationships was assessed for three generations. The risk for early onset of hypertension was proportional to the proband-oriented relative relationship score with 2% increased risk and 1% correction for incomplete capture. Conclusions: The population-based proband-oriented pedigree information system is powerful and can support various genetic descriptive and analytic epidemiological studies.
原文英語
頁(從 - 到)102-110
頁數9
期刊Journal of the American Medical Informatics Association
19
發行號1
DOIs
出版狀態已發佈 - 一月 2012

ASJC Scopus subject areas

  • Health Informatics

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